Non-alcoholic fatty liver disease in children

被引：15
作者：
Janczyk, Wojciech [1 ]
Socha, Piotr [1 ]
机构：
[1] Childrens Mem Hlth Inst, Dept Gastroenterol Hepatol & Eating Disorders, Warsaw, Poland
来源：
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2012年 / 36卷 / 03期
关键词：
D O I：
10.1016/j.clinre.2012.03.026
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Non-alcoholic fatty liver disease is increasingly prevalent in children, together with obesity. Transaminases, tests for insulin resistance, ultrasonography and MRI are variably used as surrogates markers of steatosis. Other liver diseases, such as Wilson disease, should be excluded. A liver biopsy is performed in selected cases: young children, familial history of severe disease, inconclusive tests for other pathologies, suspected advanced fibrosis, hypertransaminasemia despite weight loss and in clinical trials. Weight reduction, and changes in lifestyle, are the front-line treatment. Drug therapy is under evaluation. (C) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：297 / 300
页数：4
相关论文
共 6 条
  • [1] Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    Kleiner, DE
    Brunt, EM
    Van Natta, M
    Behling, C
    Contos, MJ
    Cummings, OW
    Ferrell, LD
    Liu, YC
    Torbenson, MS
    Unalp-Arida, A
    Yeh, M
    McCullough, AJ
    Sanyal, AJ
    [J]. HEPATOLOGY, 2005, 41 (06) : 1313 - 1321
  • [2] Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents The TONIC Randomized Controlled Trial
    Lavine, Joel E.
    Schwimmer, Jeffrey B.
    Van Natta, Mark L.
    Molleston, Jean P.
    Murray, Karen F.
    Rosenthal, Philip
    Abrams, Stephanie H.
    Scheimann, Ann O.
    Sanyal, Arun J.
    Chalasani, Naga
    Tonascia, James
    Uenalp, Aynur
    Clark, Jeanne M.
    Brunt, Elizabeth M.
    Kleiner, David E.
    Hoofnagle, Jay H.
    Robuck, Patricia R.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (16): : 1659 - 1668
  • [3] A Meta-Analysis of Randomized Trials for the Treatment of Nonalcoholic Fatty Liver Disease
    Musso, Giovanni
    Gambino, Roberto
    Cassader, Maurizio
    Pagano, Gianfranco
    [J]. HEPATOLOGY, 2010, 52 (01) : 79 - 104
  • [4] Peng L., 2011, COCHRANE DB SYST REV, V15
  • [5] Pharmacological Interventions for Nonalcoholic Fatty Liver Disease in Adults and in Children: A Systematic Review
    Socha, Piotr
    Horvath, Andrea
    Vajro, Pietro
    Dziechciarz, Piotr
    Dhawan, Anil
    Szajewska, Hania
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2009, 48 (05) : 587 - 596
  • [6] Diagnosis of Nonalcoholic Fatty Liver Disease in Children and Adolescents: Position Paper of the ESPGHAN Hepatology Committee
    Vajro, Pietro
    Lenta, Selvaggia
    Socha, Piotr
    Dhawan, Anil
    McKiernan, Patrick
    Baumann, Ulrich
    Durmaz, Ozlem
    Lacaille, Florence
    McLin, Valerie
    Nobili, Valerio
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2012, 54 (05) : 700 - 713
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