Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease

被引：64

作者：

Daborg, Jonny ^{[1
]}

Andreasson, Ulf ^{[2
]}

Pekna, Marcela ^{[3
]}

Lautner, Ronald ^{[2
]}

Hanse, Eric ^{[1
]}

Minthon, Lennart ^{[4
]}

Blennow, Kaj ^{[2
]}

Hansson, Oskar ^{[4
]}

Zetterberg, Henrik ^{[2
,5
]}

机构：

[1] Univ Gothenburg, Dept Physiol, Inst Neurosci & Physiol, Sahlgrenska Acad, S-40530 Gothenburg, Sweden

[2] Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Molndal, Sweden

[3] Univ Gothenburg, Dept Clin Neurosci & Rehabil, Inst Neurosci & Physiol, Sahlgrenska Acad, S-40530 Gothenburg, Sweden

[4] Lund Univ, Clin Memory Res Unit, Dept Clin Sci Malmo, Lund, Sweden

[5] UCL Inst Neurol, London WC1N 3BG, England

来源：

JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 07期

基金：

瑞典研究理事会;

关键词：

Alzheimer's disease; Complement; Biomarkers; C3; C4; CR1; MILD COGNITIVE IMPAIRMENT; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; SYNAPSE LOSS; ACTIVATION; BIOMARKERS; SYSTEM; CSF; DEGENERATION; CASCADE;

D O I：

10.1007/s00702-012-0797-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers A beta 42, T-tau and P-tau. We found elevated CSF levels of C3 and C4 in AD compared with MCI without progression to AD, and elevated CSF levels of CR1 in MCI-AD and AD when these groups were merged. These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful.

引用

页码：789 / 797

页数：9

共 36 条

[1] Cerebrospinal fluid β-amyloid(1-42) in Alzheimer disease -: Differences between early- and late-onset Alzheimer disease and stability during the course of disease [J].