Efficient, Solvent-Free, Multicomponent Method for Organic-Base-Catalyzed Synthesis of β-Phosphonomalonates

被引：25
作者：
Kalla, Reddi Mohan Naidu [1 ]
Park, Huiju [1 ]
Lee, Hye Ri [1 ]
Suh, Hongsuk [2 ,3 ]
Kim, Il [1 ]
机构：
[1] Pusan Natl Univ, Dept Polymer Sci & Engn, PLUS Ctr Adv Chem Technol BK21, Busan 609735, South Korea
[2] Pusan Natl Univ, Dept Chem, Busan 609735, South Korea
[3] Pusan Natl Univ, Chem Inst Funct Mat, Busan 609735, South Korea
来源：
ACS COMBINATORIAL SCIENCE | 2015年 / 17卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
beta-phosphonomalonate; multicomponent reaction; organocatalyst; solvent-free; ONE-POT SYNTHESIS; RECYCLABLE HETEROGENEOUS CATALYST; PHOSPHA-MICHAEL ADDITION; SOLID ACID CATALYST; HIGHLY EFFICIENT; SULFONIC-ACID; HYDROXYPHOSPHONATES; GAMMA-FE2O3; DESIGN;
D O I：
10.1021/acscombsci.5b00109
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient, one-pot, di-n-butylamine-catalyzed, three-component synthesis of beta-phosphonomalonates has been developed. A wide range of substrates, including aromatic and fused aromatic aldehydes, were condensed with enolizable C-H activated compounds and dialkylphosphites to give the desired products in excellent yields. This method provides an eco-friendly alternative approach to rapid construction of a diversity-oriented library of beta-phosphonomalonates.
引用
收藏
页码：691 / 697
页数：7
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