Efficient, Solvent-Free, Multicomponent Method for Organic-Base-Catalyzed Synthesis of β-Phosphonomalonates

被引：25

作者：

Kalla, Reddi Mohan Naidu ^{[1
]}

Park, Huiju ^{[1
]}

Lee, Hye Ri ^{[1
]}

Suh, Hongsuk ^{[2
,3
]}

Kim, Il ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Polymer Sci & Engn, PLUS Ctr Adv Chem Technol BK21, Busan 609735, South Korea

[2] Pusan Natl Univ, Dept Chem, Busan 609735, South Korea

[3] Pusan Natl Univ, Chem Inst Funct Mat, Busan 609735, South Korea

来源：

ACS COMBINATORIAL SCIENCE | 2015年 / 17卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

beta-phosphonomalonate; multicomponent reaction; organocatalyst; solvent-free; ONE-POT SYNTHESIS; RECYCLABLE HETEROGENEOUS CATALYST; PHOSPHA-MICHAEL ADDITION; SOLID ACID CATALYST; HIGHLY EFFICIENT; SULFONIC-ACID; HYDROXYPHOSPHONATES; GAMMA-FE2O3; DESIGN;

D O I：

10.1021/acscombsci.5b00109

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient, one-pot, di-n-butylamine-catalyzed, three-component synthesis of beta-phosphonomalonates has been developed. A wide range of substrates, including aromatic and fused aromatic aldehydes, were condensed with enolizable C-H activated compounds and dialkylphosphites to give the desired products in excellent yields. This method provides an eco-friendly alternative approach to rapid construction of a diversity-oriented library of beta-phosphonomalonates.

引用

收藏

页码：691 / 697

页数：7

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