Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

被引：0

作者：

Garncarz, Magdalena ^{[1
]}

Hulanicka, Magdalena ^{[2
]}

Parzeniecka-Jaworska, Marta ^{[1
]}

Garncarz, Jacek

Jank, Michal ^{[2
]}

机构：

[1] Warsaw Univ Life Sci, Fac Vet Med, Dept Vet Diagnost & Pathol, PL-02787 Warsaw, Poland

[2] Warsaw Univ Life Sci, Fac Vet Med, Dept Physiol Sci, PL-02787 Warsaw, Poland

来源：

BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2014年 / 58卷 / 01期

关键词：

dog; transcriptomic profiling; gene expression; valve disease; CARDIAC BIOMARKER; VALVULAR DISEASE; MATRIX; GENES;

D O I：

10.2478/bvip-2014-0021

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of the study was to demonstrate differences in the gene expression of signalling pathways between healthy dogs and dogs with chronic mitral valve disease in different heart failure groups. Blood samples were collected from 49 dogs of various breeds between 1.4 and 15.2 years of age. Isolated RNA samples were analysed for quality and integrity and the gene expression profile was determined. The study demonstrated that nucleated cells from peripheral blood can be used to assess the status of heart failure in dogs. Furthermore, significant differences in the expression of the genes were noticed between healthy dogs and dogs with clinical signs of chronic mitral valve disease. This is a preliminary non-invasive study showing the feasibility of genetic testing from peripheral blood nucleated cells, which at the same time has made it possible to set the future directions of genetic studies in clinical cases of canine chronic mitral valve disease.

引用

收藏

页码：135 / 140

页数：6

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