The involvement of ERK/CREB/Bcl-2 in depression-like behavior in prenatally stressed offspring rats

被引:52
|
作者
Guan, Lixia [1 ]
Jia, Ning [2 ]
Zhao, Xiaoyan [1 ]
Zhang, Xiaohua [1 ]
Tang, Guokui [3 ]
Yang, Li [4 ]
Sun, Hongli [1 ]
Wang, Dan [3 ]
Su, Qian [4 ]
Song, Qian [3 ]
Cai, Dongge [4 ]
Cai, Qing [5 ]
Li, Hui [6 ]
Zhu, Zhongliang [1 ,3 ]
机构
[1] Xi An Jiao Tong Univ, Coll Med, Dept Pharmacol, Xian 710061, Peoples R China
[2] Xi An Jiao Tong Univ, Coll Med, Dept Anat & Embryol, Xian 710061, Peoples R China
[3] Northwest Univ, Coll Life Sci, Shaanxi Prov Biomed Key Lab, Xian, Peoples R China
[4] Xi An Jiao Tong Univ, Coll Med, Dept Neonatol, Xian 710061, Peoples R China
[5] Tianjin Univ Tradit Chinese Med, Dept Physiol, Tianjin, Peoples R China
[6] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neonatol, Xian 710061, Peoples R China
基金
中国国家自然科学基金;
关键词
Prenatal stress; Depression; ERK2; CREB; Bcl-2; ELEMENT-BINDING PROTEIN; FORCED SWIM TEST; PITUITARY-ADRENAL AXIS; PREFRONTAL CORTEX; ANTIDEPRESSANT TREATMENT; GESTATIONAL STRESS; MAP KINASE; CYCLIC-AMP; PLASMA-CORTICOSTERONE; NEUROTROPHIC FACTOR;
D O I
10.1016/j.brainresbull.2013.08.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A number of studies reveal that prenatal stress (PS) may induce an increased vulnerability to depression in offspring. Some evidences indicate that extracellular signal-regulated kinase (ERK)-cyclic AMP responsive element binding protein (CREB) signal system may play an important role in the molecular mechanism of depression. In the present study, we examined the effects of prenatal restraint stress on depression-like behavior in one-month offspring Sprague-Dawley rats and expression of ERK2, CREB, B-cell lymphoma-2 (Bcl-2) mRNA in the hippocampus, prefrontal cortex and striatum to explore the potential role of ERK-CREB pathway in mediating the behavioral effects of PS exposure. Our findings demonstrated that PS increased immobility time in forced swimming test and decreased expression of ERK2, CREB, Bcl-2 mRNA in the hippocampus and prefrontal cortex of juvenile offspring rats except for CREB in hippocampus of male offspring. Changes induced by PS were partly prevented by MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist. These findings suggested that the ERK-CREB system might be related with the depression-like behavior in juvenile offspring rats subjected to PS, in which NMDA receptors might be involved. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 50 条
  • [1] Effects of RhoA on depression-like behavior in prenatally stressed offspring rats
    Zhou, Jiahao
    Ma, Yao
    Chen, Jinfeng
    Yao, Dan
    Feng, Caixia
    Dong, Yankai
    Ren, Yating
    Ma, Hengyu
    Wang, Zhifei
    Li, Ge
    Li, Hui
    Zhu, Zhongliang
    BEHAVIOURAL BRAIN RESEARCH, 2022, 432
  • [2] CRTC1 signaling involvement in depression-like behavior of prenatally stressed offspring rat
    Si, Yufang
    Xue, Xing
    Liu, Si
    Feng, Caixia
    Zhang, Huiping
    Zhang, Sisi
    Ren, Yating
    Ma, Hengyu
    Dong, Yankai
    Li, Hui
    Xie, Longshan
    Zhu, Zhongliang
    BEHAVIOURAL BRAIN RESEARCH, 2021, 399
  • [3] 8-OH-DPAT reverses depression-like behavior in prenatally stressed ovariectomized female offspring
    Fedotova, J.
    Pivina, S.
    Ordyan, N.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 : S414 - S415
  • [4] THE EFFECT OF MK-801 ON THE ERK-CREB SIGNAL SYSTEM IN PRENATALLY STRESSED OFFSPRING RATS
    Guan, L.
    Zhao, X.
    Zhang, X.
    Sun, H.
    Wang, D.
    Su, Q.
    Tang, G.
    Yang, L.
    Song, Q.
    Jia, N.
    Li, H.
    Zhu, Z.
    EUROPEAN PSYCHIATRY, 2013, 28
  • [5] Reduced Levels of NR1 and NR2A with Depression-Like Behavior in Different Brain Regions in Prenatally Stressed Juvenile Offspring
    Sun, Hongli
    Guan, Lixia
    Zhu, Zhongliang
    Li, Hui
    PLOS ONE, 2013, 8 (11):
  • [6] Inosine alleviates depression-like behavior and increases the activity of the ERK-CREB signaling in adolescent male rats
    Yuan, Shuai
    Jiang, Xiaofeng
    Zhou, Xinyu
    Zhang, Yuqing
    Teng, Teng
    Xie, Peng
    NEUROREPORT, 2018, 29 (14) : 1223 - 1229
  • [7] Resveratrol reverses chronic restraint stress-induced depression-like behaviour: Involvement of BDNF level, ERK phosphorylation and expression of Bcl-2 and Bax in rats
    Wang, Xueer
    Xie, Yunkai
    Zhang, Tiantian
    Bo, Shishi
    Bai, Xuemei
    Liu, Hansen
    Li, Tong
    Liu, Song
    Zhou, Yaru
    Cong, Xiang
    Wang, Zhen
    Liu, Dexiang
    BRAIN RESEARCH BULLETIN, 2016, 125 : 134 - 143
  • [8] GR/P300 Regulates MKP1 Signaling Pathway and Mediates Depression-like Behavior in Prenatally Stressed Offspring
    Wei, Bin
    Shi, Yajun
    Yu, Xi
    Cai, Yongle
    Zhao, Yan
    Song, Yueyang
    Zhao, Zejun
    Huo, Ming
    Li, Lingjun
    Gao, Qinqin
    Yu, Dongyi
    Wang, Bin
    Sun, Miao
    MOLECULAR NEUROBIOLOGY, 2024, 61 (12) : 10613 - 10628
  • [9] Grape seed proanthocyanidins improves depression-like behavior by alleviating oxidative stress and NLRP3 activation in the hippocampus of prenatally-stressed female offspring rats
    Sun, Qinru
    Jia, Ning
    Ren, Fei
    Li, Xin
    JOURNAL OF HISTOTECHNOLOGY, 2021, 44 (02) : 90 - 98
  • [10] Stimulation of D2 dopaminergic receptor corrects depression-like behaviour in prenatally stressed gonadectomised male rats
    Fedotova, J.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2014, 24 : S469 - S469