Overcoming or circumventing the stratum corneum barrier for efficient transcutaneous immunization

被引：49

作者：

Chen, Zhongjian ^{[1
]}

Lv, Yongjiu ^{[2
,3
]}

Qi, Jianping ^{[1
,2
,3
]}

Zhu, Quangang ^{[1
]}

Lu, Yi ^{[1
,2
,3
]}

Wu, Wei ^{[1
,2
,3
]}

机构：

[1] Shanghai Dermatol Hosp, Shanghai 200443, Peoples R China

[2] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery MOE, Shanghai 201203, Peoples R China

[3] PLA, Shanghai 201203, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

DISSOLVING MICRONEEDLE PATCH; TRANSDERMAL DRUG-DELIVERY; LIPID-BASED NANOCARRIERS; HAIR-FOLLICLES; VACCINE DELIVERY; IMMUNE-RESPONSES; SKIN; NANOPARTICLES; PENETRATION; DNA;

D O I：

10.1016/j.drudis.2017.09.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes because of the unique immunological characteristics of the skin. However, the stratum corneum (SC) prevents entry of most therapeutic compounds into the body. Several physical devices have been developed to overcome the SC barrier, but still damage the skin. However, by targeting antigens to the abundant perifollicular antigen-presenting cells (APCs), the transfollicular route might be a promising approach for TCI without compromising the skin barrier.

引用

页码：181 / 186

页数：6

共 58 条

[21] Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery [J].

Hu, Xiongwei ;

Fan, Wufa ;

Yu, Zhou ;

Lu, Yi ;

Qi, Jianping ;

Zhang, Jian ;

Dong, Xiaochun ;

Zhao, Weili ;

Wu, Wei .

NANOSCALE, 2016, 8 (13) :7024-7035

[22] Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers [J].

Hu, Xiongwei ;

Zhang, Jian ;

Yu, Zhou ;

Xie, Yunchang ;

He, Haisheng ;

Qi, Jianping ;

Dong, Xiaochun ;

Lu, Yi ;

Zhao, Weili ;

Wu, Wei .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2015, 11 (08) :1939-1948

[23] Penetration of pollen proteins into the skin [J].

Jacobi, U. ;

Engel, K. ;

Patzelt, A. ;

Worm, M. ;

Sterry, W. ;

Lademann, J. .

SKIN PHARMACOLOGY AND PHYSIOLOGY, 2007, 20 (06) :297-304

[24] Nanoparticulate mediated transcutaneous immunization: Myth or reality [J].

Kaurav, Monika ;

Minz, Sunita ;

Sahu, Kantrol ;

Kumar, Manoj ;

Madan, Jitender ;

Pandey, Ravi Shankar .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 12 (04) :1063-1081

[25]

Kitaoka M, 2016, METHOD PHARMACOL TOX, P349, DOI 10.1007/978-1-4939-3121-7_18

[26] Nanoparticles - An efficient carrier for drug delivery into the hair follicles [J].

Lademann, Juergen ;

Richter, Heike ;

Teichmann, Alexa ;

Otberg, Nina ;

Blume-Peytavi, Ulrike ;

Luengo, Javiana ;

Weiss, Barbara ;

Schaefer, Ulrich F. ;

Lehr, Claus-Michael ;

Wepf, Roger ;

Sterry, Wolfram .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, 66 (02) :159-164

[27] Characterization of needle-assisted jet injections [J].

Li, Xinxin ;

Ruddy, Bryan ;

Taberner, Andrew .

JOURNAL OF CONTROLLED RELEASE, 2016, 243 :195-203

[28] Recent progress in mucosal vaccine development: potential and limitations [J].

Lycke, Nils .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (08) :592-605

[29] Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells By Hair Follicles and their Transport in Mice [J].

Mahe, Brice ;

Vogt, Annika ;

Liard, Christelle ;

Duffy, Darragh ;

Abadie, Valerie ;

Bonduelle, Olivia ;

Boissonnas, Alexandre ;

Sterry, Wolfram ;

Verrier, Bernard ;

Blume-Peytavi, Ulrike ;

Combadiere, Behazine .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (05) :1156-1164

[30] Microinfusion using hollow microneedles [J].

Martanto, W ;

Moore, JS ;

Kashlan, O ;

Kamath, R ;

Wang, PM ;

O'Neal, JM ;

Prausnitz, MR .

PHARMACEUTICAL RESEARCH, 2006, 23 (01) :104-113

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