Overcoming or circumventing the stratum corneum barrier for efficient transcutaneous immunization

被引：49

作者：

Chen, Zhongjian ^{[1
]}

Lv, Yongjiu ^{[2
,3
]}

Qi, Jianping ^{[1
,2
,3
]}

Zhu, Quangang ^{[1
]}

Lu, Yi ^{[1
,2
,3
]}

Wu, Wei ^{[1
,2
,3
]}

机构：

[1] Shanghai Dermatol Hosp, Shanghai 200443, Peoples R China

[2] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery MOE, Shanghai 201203, Peoples R China

[3] PLA, Shanghai 201203, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

DISSOLVING MICRONEEDLE PATCH; TRANSDERMAL DRUG-DELIVERY; LIPID-BASED NANOCARRIERS; HAIR-FOLLICLES; VACCINE DELIVERY; IMMUNE-RESPONSES; SKIN; NANOPARTICLES; PENETRATION; DNA;

D O I：

10.1016/j.drudis.2017.09.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes because of the unique immunological characteristics of the skin. However, the stratum corneum (SC) prevents entry of most therapeutic compounds into the body. Several physical devices have been developed to overcome the SC barrier, but still damage the skin. However, by targeting antigens to the abundant perifollicular antigen-presenting cells (APCs), the transfollicular route might be a promising approach for TCI without compromising the skin barrier.

引用

页码：181 / 186

页数：6

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