Synthesis and antimicrobial activity of new 4-(benzylsulfanyl)pyridine derivatives

被引：23
|
作者：
Klimesová, V [1 ]
Svoboda, M
Waisser, K
Pour, M
Kaustová, J
机构：
[1] Charles Univ, Fac Pharm, Dept Inorgan & Organ Chem, Hradec Kralove 50005, Czech Republic
[2] Reg Inst Hyg, Natl Reference Lab Mycobacterium Kansasii, Ostrava 72892, Czech Republic
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1999年 / 64卷 / 02期
关键词：
pyridinecarbonitriles; pyridinecarbothioamides; tuberculostatics; antimycobacterial activity; antifungal activity; QSAR;
D O I：
10.1135/cccc19990417
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 4-(benzylsulfanyl)pyridine-2-carbonitriles 2 and 4-(benzylsulfanyl)pyridine-2-carbothioamides 3 was synthesized and their antimycobacterial and antifungal activities were tested. The prepared compounds exhibit significant activity both against M. tuberculosis and nontuberculous mycobacteria. The most active compounds show the MICs of 4 mu mol/l. The antifungal activities of 2 are very weak, compounds 3 are inactive against all the tested fungi.
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收藏
页码：417 / 434
页数：18
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