Oxidative stress response and Nrf2 signaling in aging

被引：627
作者：
Zhang, Hongqiao [1 ]
Davies, Kelvin J. A. [1 ,2 ]
Forman, Henry Jay [1 ,3 ]
机构：
[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Dornsife Coll Letters Arts & Sci, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dornsife Coll Letters Arts & Sci, Dept Biol Sci, Div Mol & Computat Biol, Los Angeles, CA 90089 USA
[3] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2015年 / 88卷
关键词：
Aging; Antioxidant; Nrf2; Oxidative stress; Transcription factor; Free radicals; AGE-RELATED-CHANGES; GLUTAMATE-CYSTEINE LIGASE; TRANSCRIPTION FACTOR NRF2; CREB-BINDING-PROTEIN; NF-KAPPA-B; HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; MANGANESE SUPEROXIDE-DISMUTASE; ENDOPLASMIC-RETICULUM STRESS; ELEMENT-MEDIATED EXPRESSION; DRUG-METABOLIZING-ENZYMES;
D O I：
10.1016/j.freeradbiomed.2015.05.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress dedines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：314 / 336
页数：23
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