Ln(OTf)3-catalysed highly regioselective alcoholysis of 2,3-epoxy alcohols

被引：9

作者：

Nakamura, Daichi ^{[1
]}

Sasano, Yusuke ^{[1
]}

Iwabuchi, Yoshiharu ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 14期

关键词：

ASYMMETRIC EPOXIDATION; ALLYLIC ALCOHOLS; ENANTIOSELECTIVE EPOXIDATION; NUCLEOPHILIC OPENINGS; BETA-CYCLODEXTRIN; EFFICIENT; EPOXYALCOHOLS; DERIVATIVES; AMINOLYSIS; STRATEGIES;

D O I：

10.1039/c8ob02448k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselectivity of Ln(OTf)(3)-catalysed alcoholysis of 2,3- and 3,4-epoxy alcohols was closely investigated to expand the scope of the transformations. The synthetic use was demonstrated by application to the construction of 4-propoxy-5-hydroxy-2,3-pentanedione (C4-propoxy-HPD), which is a potent synthetic mediator in AI-2 quorum sensing.

引用

页码：3581 / 3589

页数：9

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