Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29)

被引：78
|
作者：
Stewart, MS
Davis, RL
Walsh, LP
Pence, BC
机构：
[1] TEXAS TECH UNIV, HLTH SCI CTR, DEPT PATHOL, LUBBOCK, TX 79430 USA
[2] TEXAS TECH UNIV, DEPT NUTR, LUBBOCK, TX 79430 USA
来源：
CANCER LETTERS | 1997年 / 117卷 / 01期
关键词：
selenite; glutathione; colon cancer; differentiation; apoptosis;
D O I：
10.1016/S0304-3835(97)00212-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To explore the mechanism(s) by which selenium (Se) exerts its cancer chemopreventive activity, we studied the effect of selenite (0-100 mu M) on cell growth, viability, differentiation, detachment, DNA fragmentation and apoptosis in human colonic carcinoma cells (HT29). Selenite (greater than or equal to 5 mu M) decreased cell growth, increased cell detachment and decreased intracellular levels of reduced glutathione (GSH), whereas greater than or equal to 10 mu M selenite induced cell differentiation and apoptosis. The chemopreventive effects of selenite may be related in part to the generation of reactive oxygen species (ROS) resulting from the reaction between selenite and GSH. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：35 / 40
页数：6
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