Where will new antibiotics come from?

被引：575
作者：
Walsh, C [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2003年 / 1卷 / 01期
关键词：
D O I：
10.1038/nrmicro727
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
There is a constant need for new antibacterial drugs owing to the inevitable development of resistance that follows the introduction of antibiotics to the clinic. When a new class of antibiotic is introduced, it is effective at first, but will eventually select for survival of the small fraction of bacterial populations that have an intrinsic or acquired resistance mechanism. Pathogens that are resistant to multiple drugs emerge around the globe, so how robust are antibiotic discovery processes?
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页码：65 / 70
页数：6
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