The value of a complete blood count in predicting cancer of the colon

被引：147

作者：

Spell, DW ^{[1
]}

Jones, DV ^{[1
]}

Harper, WF ^{[1
]}

Bessman, JD ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Internal Med, Div Hematol Oncol, Galveston, TX 77550 USA

来源：

CANCER DETECTION AND PREVENTION | 2004年 / 28卷 / 01期

关键词：

anemia; iron deficiency; colorectal neoplasms/prevention and control; diagnostic techniques; digestive system; erythrocyte indices;

D O I：

10.1016/j.cdp.2003.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mortality from colon cancer could be reduced with routine screening, yet screening rates are low. Current screening tools are limited by expense and suboptimal acceptance. A retrospective case-control study of all cases of colon cancer diagnosed at our institution over a 5-year period was performed to determine the frequency of blood count abnormalities in these patients upon presentation. One hundred twenty-seven patients had right-sided colon cancer: 107 (84%) had an elevated red cell distribution width (RDW); 87 (69%) had anemia; and 70 (55%) had a low mean corpuscular volume (MCV). Ninety-eight patients had left-sided colon cancer: 49 (50%) had an elevated red cell distribution width; 43 (44%) had anemia; and 22 (22%) had a low mean corpuscular volume. The red cell distribution width was 84% sensitive and 88% specific for right-sided colon cancer. An elevated red cell distribution width may help better identify those patients who should be referred for full colonoscopy. (C) 2004 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.

引用

页码：37 / 42

页数：6

共 27 条

[1] DETECTION OF IRON-DEFICIENCY ANEMIA [J].

BESSMAN, JD ;

MCCLURE, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (12) :1649-1649

[2]

Bini EJ, 2001, GASTROINTEST ENDOSC, V53, pAB178

[3]

BRUCKNER HW, 2000, CANC MED, P1472

[4] American Cancer Society guidelines for screening and surveillance for early detection of colorectal polyps and cancer: Update 1997 [J].

Byers, T ;

Levin, B ;

Rothenberger, D ;

Dodd, GD ;

Smith, RA .

CA-A CANCER JOURNAL FOR CLINICIANS, 1997, 47 (03) :154-&

[5]

COOK IJ, 1986, B MED J, V292, P380

[6]

GHASSEMI KF, 1996, GASTROENTEROLOGY, V110, pA518

[7]

GORDON SR, 1994, AM J GASTROENTEROL, V89, P1963

[8]

GRIFFITHS EK, 1991, CANCER DETECT PREV, V15, P303

[9] Randomised controlled trial of faecal-occult-blood screening for colorectal cancer [J].

Hardcastle, JD ;

Chamberlain, JO ;

Robinson, MHE ;

Moss, SM ;

Amar, SS ;

Balfour, TW ;

James, PD ;

Mangham, CM .

LANCET, 1996, 348 (9040) :1472-1477

[10] Cancer statistics, 2003 [J].

Jemal, A ;

Murray, T ;

Samuels, A ;

Ghafoor, A ;

Ward, E ;

Thun, MJ .

CA-A CANCER JOURNAL FOR CLINICIANS, 2003, 53 (01) :5-26

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