Antioxidant action of ergothioneine: Assessment of its ability to scavenge peroxynitrite

被引：109

作者：

Aruoma, OI ^{[1
]}

Whiteman, M ^{[1
]}

England, TG ^{[1
]}

Halliwell, B ^{[1
]}

机构：

[1] UNIV LONDON,UNIV LONDON KINGS COLL,PHARMACOL GRP,LONDON SW3 6LX,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 231卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.6109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superoxide radical (O-2(.-)) and nitric oxide (NO.) combine very rapidly to form peroxynitrite (ONOO-), a reactive tissue damaging nitrogen species thought to be involved in the pathology of several chronic diseases. The natural product ergothioneine protects against the nitration of tyrosine and the inactivation of alpha(1)-antiproteinase by ONOO-. Ergothioneine merits further investigation as a biological and therapeutic antioxidant agent. (C) 1997 Academic Press.

引用

页码：389 / 391

页数：3

共 41 条

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