A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside

被引：14

作者：

Radi, Giulia ^{[1
]}

Campanti, Anna ^{[1
]}

Diotallevi, Federico ^{[1
]}

Martina, Emanuela ^{[1
]}

Marani, Andrea ^{[1
]}

Offidani, Annamaria ^{[1
]}

机构：

[1] Polytech Marche Univ, Dermatol Clin, Dept Clin & Mol Sci, I-60126 Ancona, Italy

来源：

BIOMEDICINES | 2022年 / 10卷 / 11期

关键词：

atopic dermatitis; pathophysiology; small molecules; biologics; novel treatments; DOUBLE-BLIND; EPIDERMAL BARRIER; BASIC SCIENCE; PLACEBO; PHASE-3; ADOLESCENTS; RECEPTORS; CYTOKINES; EFFICACY; ADULTS;

D O I：

10.3390/biomedicines10112700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to the discovery of several new potential therapeutic targets, and research in the field of new molecules with therapeutic perspectives is boiling, with more than 70 new promising drugs in development. The aim of this systematic review is to provide the state of the art on the current knowledge concerning the pathophysiology of the disease and on novel agents currently being investigated for AD, and to highlight which type of evolution is going to take place in therapeutic approaches of atopic dermatitis in the coming years.

引用

页数：28

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