A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside

被引：13
作者：
Radi, Giulia [1 ]
Campanti, Anna [1 ]
Diotallevi, Federico [1 ]
Martina, Emanuela [1 ]
Marani, Andrea [1 ]
Offidani, Annamaria [1 ]
机构：
[1] Polytech Marche Univ, Dermatol Clin, Dept Clin & Mol Sci, I-60126 Ancona, Italy
来源：
BIOMEDICINES | 2022年 / 10卷 / 11期
关键词：
atopic dermatitis; pathophysiology; small molecules; biologics; novel treatments; DOUBLE-BLIND; EPIDERMAL BARRIER; BASIC SCIENCE; PLACEBO; PHASE-3; ADOLESCENTS; RECEPTORS; CYTOKINES; EFFICACY; ADULTS;
D O I：
10.3390/biomedicines10112700
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to the discovery of several new potential therapeutic targets, and research in the field of new molecules with therapeutic perspectives is boiling, with more than 70 new promising drugs in development. The aim of this systematic review is to provide the state of the art on the current knowledge concerning the pathophysiology of the disease and on novel agents currently being investigated for AD, and to highlight which type of evolution is going to take place in therapeutic approaches of atopic dermatitis in the coming years.
引用
收藏
页数：28
相关论文
共 89 条
  • [11] Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial
    Bissonnette, R.
    Papp, K. A.
    Poulin, Y.
    Gooderham, M.
    Raman, M.
    Mallbris, L.
    Wang, C.
    Purohit, V.
    Mamolo, C.
    Papacharalambous, J.
    Ports, W. C.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (05) : 902 - 911
  • [12] Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis A Randomized Clinical Trial
    Blauvelt, Andrew
    Teixeira, Henrique D.
    Simpson, Eric L.
    Costanzo, Antonio
    De Bruin-Weller, Marjolein
    Barbarot, Sebastien
    Prajapati, Vimal H.
    Lio, Peter
    Hu, Xiaofei
    Wu, Tianshuang
    Liu, John
    Ladizinski, Barry
    Chu, Alvina D.
    Eyerich, Kilian
    [J]. JAMA DERMATOLOGY, 2021, 157 (09) : 1047 - 1055
  • [13] Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis
    Byrd, Allyson L.
    Deming, Clay
    Cassidy, Sara K. B.
    Harrison, Oliver J.
    Ng, Weng-Ian
    Conlan, Sean
    Belkaid, Yasmine
    Segre, Julia A.
    Kong, Heidi H.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (397)
  • [14] Comorbidities and treatment patterns in adult patients with atopic dermatitis: results from a nationwide multicenter study
    Campanati, A.
    Bianchelli, T.
    Gesuita, R.
    Foti, C.
    Malara, G.
    Micali, G.
    Amerio, P.
    Rongioletti, F.
    Corazza, M.
    Patrizi, A.
    Peris, K.
    Pimpinelli, N.
    Parodi, A.
    Fargnoli, M. C.
    Cannavo, S. P.
    Pigatto, P.
    Pellacani, G.
    Ferrucci, S. M.
    Argenziano, G.
    Cusano, F.
    Fabbrocini, G.
    Stingeni, L.
    Potenza, M. C.
    Romanelli, M.
    Bianchi, L.
    Offidani, A.
    Romita, P.
    Musumeci, M. L.
    Piras, V.
    Borghi, A.
    Loi, C.
    Gori, N.
    Prigano, F.
    Gallo, R.
    Esposito, M.
    Campitello, A.
    Bolzano, L.
    Tavecchio, S.
    Calabrese, G.
    Di Costanzo, L.
    Hansel, K.
    Skroza, N.
    Tolino, E.
    Tonini, G.
    Talamonti, M.
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2022, 314 (06) : 593 - 603
  • [15] The less-known face of dupilumab: its role in mesenchymal stem cells by interleukin-13 modulation
    Campanati, A.
    Di Vincenzo, M.
    Radi, G.
    Rizzetto, G.
    Carnevale, G.
    Marchi, S.
    Orciani, M.
    Offidani, A.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2021, 185 (01) : 217 - 219
  • [16] Mesenchymal Stem Cells Profile in Adult Atopic Dermatitis and Effect of IL4-IL13 Inflammatory Pathway Inhibition In Vivo: Prospective Case-Control Study
    Campanati, Anna
    Orciani, Monia
    Marani, Andrea
    Di Vincenzo, Mariangela
    Magi, Simona
    Gregoriou, Stamatios
    Diotallevi, Federico
    Martina, Emanuela
    Radi, Giulia
    Offidani, Annamaria
    [J]. JOURNAL OF CLINICAL MEDICINE, 2022, 11 (16)
  • [17] Janus kinase inhibitors for atopic dermatitis: a promising treatment modality
    Cartron, A. M.
    Nguyen, T. H.
    Roh, Y. S.
    Kwatra, M. M.
    Kwatra, S. G.
    [J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2021, 46 (05) : 820 - 824
  • [18] Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis
    Chen, Yi-Ling
    Gutowska-Owsiak, Danuta
    Hardman, Clare S.
    Westmoreland, Melanie
    MacKenzie, Teena
    Cifuentes, Liliana
    Waithe, Dominic
    Lloyd-Lavery, Antonia
    Marquette, Allison
    Londei, Marco
    Ogg, Graham
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (515)
  • [19] The genetics of atopic dermatitis
    Chien, Yin-Hsiu
    Hwu, Wuh-Liang
    Chiang, Bor-Luen
    [J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2007, 33 (03) : 178 - 190
  • [20] Chiricozzi A, 2020, IMMUNOTARGETS THER, V9, P151, DOI 10.2147/ITT.S260370
123456789