A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside

被引：13
作者：
Radi, Giulia [1 ]
Campanti, Anna [1 ]
Diotallevi, Federico [1 ]
Martina, Emanuela [1 ]
Marani, Andrea [1 ]
Offidani, Annamaria [1 ]
机构：
[1] Polytech Marche Univ, Dermatol Clin, Dept Clin & Mol Sci, I-60126 Ancona, Italy
来源：
BIOMEDICINES | 2022年 / 10卷 / 11期
关键词：
atopic dermatitis; pathophysiology; small molecules; biologics; novel treatments; DOUBLE-BLIND; EPIDERMAL BARRIER; BASIC SCIENCE; PLACEBO; PHASE-3; ADOLESCENTS; RECEPTORS; CYTOKINES; EFFICACY; ADULTS;
D O I：
10.3390/biomedicines10112700
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to the discovery of several new potential therapeutic targets, and research in the field of new molecules with therapeutic perspectives is boiling, with more than 70 new promising drugs in development. The aim of this systematic review is to provide the state of the art on the current knowledge concerning the pathophysiology of the disease and on novel agents currently being investigated for AD, and to highlight which type of evolution is going to take place in therapeutic approaches of atopic dermatitis in the coming years.
引用
收藏
页数：28
相关论文
共 89 条
  • [1] Skin pH: From Basic Science to Basic Skin Care
    Ali, Saba M.
    Yosipovitch, Gil
    [J]. ACTA DERMATO-VENEREOLOGICA, 2013, 93 (03) : 261 - 267
  • [2] Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release
    Archer, Nathan K.
    Jo, Jay-Hyun
    Lee, Steven K.
    Kim, Dongwon
    Smith, Barbara
    Ortines, Roger V.
    Wang, Yu
    Marchitto, Mark C.
    Ravipati, Advaitaa
    Cai, Shuting S.
    Dillen, Carly A.
    Liu, Haiyun
    Miller, Robert J.
    Ashbaugh, Alyssa G.
    Uppal, Angad S.
    Oyoshi, Michiko K.
    Malhotra, Nidhi
    Hoff, Sabine
    Garza, Luis A.
    Kong, Heidi H.
    Segre, Julia A.
    Geha, Raif S.
    Miller, Lloyd S.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (04) : 1426 - +
  • [3] Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI 10.1080/1364557032000119616
  • [4] Substance P activates Mas-related G protein-coupled receptors to induce itch
    Azimi, Ehsan
    Reddy, Vemuri B.
    Seadi Pereira, Paula Juliana
    Talbot, Sebastien
    Woolf, Clifford J.
    Lerner, Ethan A.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (02) : 447 - +
  • [5] Dual action of neurokinin-1 antagonists on Mas-related GPCRs
    Azimi, Ehsan
    Reddy, Vemuri B.
    Shade, Kai-Ting C.
    Anthony, Robert M.
    Talbot, Sebastien
    Pereira, Paula Juliana Seadi
    Lerner, Ethan A.
    [J]. JCI INSIGHT, 2016, 1 (16):
  • [6] Epidemiology of atopic dermatitis in adults: Results from an international survey
    Barbarot, S.
    Auziere, S.
    Gadkari, A.
    Girolomoni, G.
    Puig, L.
    Simpson, E. L.
    Margolis, D. J.
    de Bruin-Weller, M.
    Eckert, L.
    [J]. ALLERGY, 2018, 73 (06) : 1284 - 1293
  • [7] Biologic Therapies in HIV-infected Patients with Psoriasis: An Italian Experience
    Bardazzi, Federico
    Magnano, Michela
    Campanati, Anna
    Loconsole, Francesco
    Carpentieri, Antonio
    Potenza, Concetta
    Bernardini, Nicoletta
    Di Lernia, Vito
    Carrera, Carlo
    Raone, Beatrice
    Patrizi, Annalisa
    Loi, Camilla
    [J]. ACTA DERMATO-VENEREOLOGICA, 2017, 97 (08) : 989 - 990
  • [8] HUMAN EPIDERMAL LANGERHANS CELLS EXPRESS THE HIGH-AFFINITY RECEPTOR FOR IMMUNOGLOBULIN-E (FC-EPSILON-RI)
    BIEBER, T
    DELASALLE, H
    WOLLENBERG, A
    HAKIMI, J
    CHIZZONITE, R
    RING, J
    HANAU, D
    DELASALLE, C
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (05) : 1285 - 1290
  • [9] Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis
    Bieber, Thomas
    Simpson, Eric L.
    Silverberg, Jonathan I.
    Thaci, Diamant
    Paul, Carle
    Pink, Andrew E.
    Kataoka, Yoko
    Chu, Chia-Yu
    DiBonaventura, Marco
    Rojo, Ricardo
    Antinew, Jeremias
    Ionita, Ileana
    Sinclair, Rodney
    Forman, Seth
    Zdybski, Jacek
    Biswas, Pinaki
    Malhotra, Bimal
    Zhang, Fan
    Valdez, Hernan
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (12) : 1101 - 1112
  • [10] The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: results from a randomized double-blind placebo-controlled study
    Bissonnette, R.
    Maari, C.
    Forman, S.
    Bhatia, N.
    Lee, M.
    Fowler, J.
    Tyring, S.
    Pariser, D.
    Sofen, H.
    Dhawan, S.
    Zook, M.
    Zammit, D. J.
    Usansky, H.
    Denis, L.
    Rao, N.
    Song, T.
    Pavel, A. B.
    Guttman-Yassky, E.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2019, 181 (04) : 733 - 742
123456789