Antigen delivery systems for veterinary vaccine development Viral-vector based delivery systems

被引：51

作者：

Brun, Alejandro ^{[1
]}

Albina, Emmanuel ^{[2
]}

Barret, Tom ^{[3
]}

Chapman, David A. G. ^{[3
]}

Czub, Markus ^{[4
]}

Dixon, Linda K. ^{[3
]}

Keil, Guenther M. ^{[6
]}

Klonjkowski, Bernard ^{[7
]}

Le Potier, Marie-Frederique ^{[5
]}

Libeau, Genevieve ^{[2
]}

Ortego, Javier ^{[1
]}

Richardson, Jennifer ^{[7
]}

Takamatsu, Haru-H. ^{[3
]}

机构：

[1] CISA INIA, Madrid 28130, Spain

[2] CIRAD, UMR, F-34398 Montpellier 05, France

[3] Inst Anim Hlth, Pirbright GU24 ONF, England

[4] Univ Calgary, Fac Vet Med, Calgary, AB T2N 1N4, Canada

[5] AFSSA, F-22440 Ploufragan, France

[6] Bundesforsch Inst Tiergesundheit, Friedrich Loeffler Inst, D-17493 Greifswald, Germany

[7] ENVA, AFSSA, INRA, UMR Virol 1161, F-94704 Maisons Alfort, France

来源：

VACCINE | 2008年 / 26卷 / 51期

关键词：

Antigen delivery systems; Veterinary vaccines; Modified live virus; Viral vectors; Poxvirus vectors; Herpesvirus vectors; Adenovirus vectors; Baculovirus vectors; Positive strand RNA virus vectors; Negative strand RNA virus vectors;

D O I：

10.1016/j.vaccine.2008.09.044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational design of vaccines effective against viral epizootic diseases. This paper reviews most of the viral-vector based antigen delivery systems(ADSs) recently developed for vaccine testing in veterinary species, including attenuated virus and DNA and RNA viral vectors. Besides their usefulness in vaccinology, these ADSs constitute invaluable tools to researchers for understanding the nature Of protective responses in different species, opening the possibility of modulating or potentiating relevant immune mechanisms involved in protection. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6508 / 6528

页数：21

共 344 条

[1] Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice [J].