Secondary structure dependent self-assembly of β-peptides into nanosized fibrils and membranes

被引：99
作者：
Martinek, TA
Hetényi, A
Fülöp, L
Mándity, IM
Tóth, GK
Dékány, I
Fülöp, F
机构：
[1] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary
[2] Univ Szeged, Dept Med Chem, H-6720 Szeged, Hungary
[3] Univ Szeged, Hungarian Acad Sci, Nanostruct Mat Res Grp, H-6720 Szeged, Hungary
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期
关键词：
beta-peptides; foldamers; nanomaterials; peptide mimetics; self-assembly;
D O I：
10.1002/anie.200504158
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) In control: The secondary structure dependent self-assembly of β-peptides in solution proves that natural biopolymers are not unique in their highly structured conformational behavior. Stereochemically controlled secondary structural units of β-peptide strands and helices intrinsically self-associate into pleated-sheet sandwiches (see picture) and helix-bundle membranes, respectively. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2396 / 2400
页数：5
相关论文
共 34 条
[1]  
[Anonymous], ANGEW CHEM
[2]   Synthesis and characterization of trans-2-aminocyclohexanecarboxylic acid oligomers:: An unnatural helical secondary structure and implications for β-peptide tertiary structure [J].
Appella, DH ;
Christianson, LA ;
Karle, IL ;
Powell, DR ;
Gellman, SH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (26) :6206-6212
[3]   Residue-based control of helix shape in beta-peptide oligomers [J].
Appella, DH ;
Christianson, LA ;
Klein, DA ;
Powell, DR ;
Huang, XL ;
Barchi, JJ ;
Gellman, SH .
NATURE, 1997, 387 (6631) :381-384
[4]   Synthetic biology for nanotechnology [J].
Ball, P .
NANOTECHNOLOGY, 2005, 16 (01) :R1-R8
[5]  
Branden C., 1998, Introduction to Protein Structure
[6]   Three-dimensional organization of helices:: Design principles for nucleobase-functionalized β-peptides [J].
Chakraborty, P ;
Diederichsen, U .
CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (11) :3207-3216
[7]   β-peptides:: From structure to function [J].
Cheng, RP ;
Gellman, SH ;
DeGrado, WF .
CHEMICAL REVIEWS, 2001, 101 (10) :3219-3232
[8]  
CHENG RP, 2001, J AM CHEM SOC, V123, P11564
[9]   Polymersomes: Tough vesicles made from diblock copolymers [J].
Discher, BM ;
Won, YY ;
Ege, DS ;
Lee, JCM ;
Bates, FS ;
Discher, DE ;
Hammer, DA .
SCIENCE, 1999, 284 (5417) :1143-1146
[10]   β-amyloid-derived pentapeptide RIIGLa inhibits Aβ1-42 aggregation and toxicity [J].
Fülöp, L ;
Zarándi, M ;
Datki, Z ;
Soós, K ;
Penke, B .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 324 (01) :64-69
1234