Matrix metalloproteinases and vascular endothelial growth factor expression in canine leukaemias

被引：6

作者：

Arico, Arianna ^{[1
]}

Giantin, Mery ^{[1
]}

Gelain, Mariaelena ^{[1
]}

Riondato, Fulvio ^{[3
]}

Mortarino, Michele ^{[2
]}

Comazzi, Stefano ^{[2
]}

Dacasto, Mauro ^{[1
]}

Castagnaro, Massimo ^{[1
]}

Aresu, Luca ^{[1
]}

机构：

[1] Univ Padua, Dept Comparat Biomed & Food Sci, I-35020 Agripolis Legnaro, PD, Italy

[2] Univ Milan, Dept Anim Pathol Publ Hlth & Vet Hyg, Fac Vet Med, I-20133 Milan, Italy

[3] Univ Turin, Dept Anim Pathol, Fac Vet Med, I-10095 Grugliasco, TO, Italy

来源：

VETERINARY JOURNAL | 2013年 / 196卷 / 02期

关键词：

Dog; Leukaemia: MMP; IMPs; VEGF; ANGIOGENESIS;

D O I：

10.1016/j.tvjl.2012.10.004

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) play a coordinated role during neoplastic invasion and proliferation. VEGF and MMPs expression was investigated in canine leukaemias by immunocytochemistry (MMP-9, MMP-2, VEGF-A) and quantitative RT-PCR (MMP-2, MMP-9, MT1-MMP, TIMP-1, TIMP-2, RECK, VEGF-A, VEGF-164). Blood samples were obtained from dogs with acute leukaemia (AL; n = 11) and chronic lymphocytic leukaemia (CLL; n = 12). Levels of MMP-9, TIMP-1 and VEGF-A were higher in CLL than AL and controls. Expression of TIMP-2 and MT1-MMP mRNA was significantly higher in AL than CLL. Significant positive correlations were found between MMP-9 and TIMP-1 and between MMP-9 and VEGF-A in CLL. These results suggest a potential role of MMP-9, MT1-MMP, TIMP-1, TIMP-2 and VEGF in tissue migration and angiogenesis in canine leukaemia. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：260 / 262

页数：3

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