Immune Recovery After Starting ART in HIV-Infected Patients Presenting and Not Presenting With Tuberculosis in South Africa

被引：13
|
作者：
Schomaker, Michael [1 ]
Egger, Matthias [2 ]
Maskew, Mhairi [3 ]
Garone, Daniela [4 ]
Prozesky, Hans [5 ,6 ]
Hoffmann, Christopher J. [7 ,8 ]
Boulle, Andrew [1 ]
Fenner, Lukas [2 ,9 ,10 ]
机构：
[1] Univ Cape Town, Sch Publ Hlth & Family Med, CIDER, ZA-7925 Cape Town, South Africa
[2] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
[3] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med,Hlth Econ & Epidemiol Res Off, Johannesburg, South Africa
[4] Med Sans Frontieres, Khayelitsha ART Programme, Cape Town, South Africa
[5] Univ Stellenbosch, Dept Med, Div Infect Dis, Cape Town, South Africa
[6] Tygerberg Hosp, Cape Town, South Africa
[7] Aurum Inst, Johannesburg, South Africa
[8] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[9] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
[10] Univ Basel, Basel, Switzerland
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 63卷 / 01期
关键词：
tuberculosis; HIV; antiretroviral treatment; immune; response; CD4 cell count; linear mixed model; SUB-SAHARAN AFRICA; ANTIRETROVIRAL TREATMENT PROGRAM; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; INCOME COUNTRIES; THERAPY; ADULTS; ACTIVATION; IMPACT; AIDS;
D O I：
10.1097/QAI.0b013e318288b39d
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied the immune response after starting anti-retroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/mL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.
引用
收藏
页码：142 / 145
页数：4
相关论文
共 50 条
  • [41] Effect of tuberculosis infection on mortality of HIV-infected patients in Northern Tanzania
    Mollel, Edson W.
    Todd, Jim
    Mahande, Michael J.
    Msuya, Sia E.
    TROPICAL MEDICINE AND HEALTH, 2020, 48 (01)
  • [42] Undiagnosed Active Tuberculosis in HIV-Infected Patients Commencing Antiretroviral Therapy
    Meintjes, Graeme
    Wilkinson, Robert J.
    CLINICAL INFECTIOUS DISEASES, 2010, 51 (07) : 830 - 832
  • [43] Impact of drug-resistant tuberculosis on the survival of HIV-infected patients
    Sungkanuparph, S.
    Eampokalap, B.
    Chottanapund, S.
    Thongyen, S.
    Manosuthi, W.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2007, 11 (03) : 325 - 330
  • [44] A PROSPECTIVE-STUDY OF THE RISK OF TUBERCULOSIS AMONG HIV-INFECTED PATIENTS
    GUELAR, A
    GATELL, JM
    VERDEJO, J
    PODZAMCZER, D
    LOZANO, L
    AZNAR, E
    MIRO, JM
    MALLOLAS, J
    ZAMORA, L
    GONZALEZ, J
    SORIANO, E
    AIDS, 1993, 7 (10) : 1345 - 1349
  • [45] Effect of tuberculosis infection on mortality of HIV-infected patients in Northern Tanzania
    Edson W. Mollel
    Jim Todd
    Michael J. Mahande
    Sia E. Msuya
    Tropical Medicine and Health, 48
  • [46] Approach to acute kidney injury in HIV-infected patients in South Africa
    Boswell, Michael T.
    Rossouw, Theresa M.
    SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE, 2017, 18 (01)
  • [47] Impaired CD4 T-Cell Count Response to Combined Antiretroviral Therapy in Antiretroviral-Naive HIV-Infected Patients Presenting With Tuberculosis as AIDS-Defining Condition
    Cingolani, Antonella
    Lepri, Alessandro Cozzi
    Castagna, Antonella
    Goletti, Delia
    De Luca, Andrea
    Scarpellini, Paolo
    Fanti, Iuri
    Antinori, Andrea
    Monforte, Antonella d'Arminio
    Girardi, Enrico
    CLINICAL INFECTIOUS DISEASES, 2012, 54 (06) : 853 - 861
  • [48] Current situation of the pharmacogenetics of immune recovery in treated HIV-infected patients
    Vidal, Francesc
    Leal, Manuel
    Alcami, Jose
    Domingo, Pere
    PHARMACOGENOMICS, 2014, 15 (05) : 569 - 572
  • [49] Twice-weekly, directly observed treatment for HIV-infected and uninfected tuberculosis patients: cohort study in rural South Africa
    Davies, GR
    Connolly, C
    Sturm, AW
    McAdam, KPWJ
    Wilkinson, D
    AIDS, 1999, 13 (07) : 811 - 817
  • [50] Nodal cryptococcal immune reconstitution inflammatory syndrome masquerading as tuberculosis in an HIV-infected patient
    Tweddle, A.
    Davies, S. J.
    Topping, W.
    Whitehorn, J.
    Falzon, M.
    Miller, R. F.
    INTERNATIONAL JOURNAL OF STD & AIDS, 2012, 23 (03) : 216 - 218
12345