Immune Recovery After Starting ART in HIV-Infected Patients Presenting and Not Presenting With Tuberculosis in South Africa

被引：13

作者：

Schomaker, Michael ^{[1
]}

Egger, Matthias ^{[2
]}

Maskew, Mhairi ^{[3
]}

Garone, Daniela ^{[4
]}

Prozesky, Hans ^{[5
,6
]}

Hoffmann, Christopher J. ^{[7
,8
]}

Boulle, Andrew ^{[1
]}

Fenner, Lukas ^{[2
,9
,10
]}

机构：

[1] Univ Cape Town, Sch Publ Hlth & Family Med, CIDER, ZA-7925 Cape Town, South Africa

[2] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[3] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med,Hlth Econ & Epidemiol Res Off, Johannesburg, South Africa

[4] Med Sans Frontieres, Khayelitsha ART Programme, Cape Town, South Africa

[5] Univ Stellenbosch, Dept Med, Div Infect Dis, Cape Town, South Africa

[6] Tygerberg Hosp, Cape Town, South Africa

[7] Aurum Inst, Johannesburg, South Africa

[8] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[9] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[10] Univ Basel, Basel, Switzerland

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 63卷 / 01期

关键词：

tuberculosis; HIV; antiretroviral treatment; immune; response; CD4 cell count; linear mixed model; SUB-SAHARAN AFRICA; ANTIRETROVIRAL TREATMENT PROGRAM; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; INCOME COUNTRIES; THERAPY; ADULTS; ACTIVATION; IMPACT; AIDS;

D O I：

10.1097/QAI.0b013e318288b39d

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the immune response after starting anti-retroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/mL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.

引用

页码：142 / 145

页数：4

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