Immune Recovery After Starting ART in HIV-Infected Patients Presenting and Not Presenting With Tuberculosis in South Africa

被引：13
|
作者：
Schomaker, Michael [1 ]
Egger, Matthias [2 ]
Maskew, Mhairi [3 ]
Garone, Daniela [4 ]
Prozesky, Hans [5 ,6 ]
Hoffmann, Christopher J. [7 ,8 ]
Boulle, Andrew [1 ]
Fenner, Lukas [2 ,9 ,10 ]
机构：
[1] Univ Cape Town, Sch Publ Hlth & Family Med, CIDER, ZA-7925 Cape Town, South Africa
[2] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
[3] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med,Hlth Econ & Epidemiol Res Off, Johannesburg, South Africa
[4] Med Sans Frontieres, Khayelitsha ART Programme, Cape Town, South Africa
[5] Univ Stellenbosch, Dept Med, Div Infect Dis, Cape Town, South Africa
[6] Tygerberg Hosp, Cape Town, South Africa
[7] Aurum Inst, Johannesburg, South Africa
[8] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[9] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
[10] Univ Basel, Basel, Switzerland
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 63卷 / 01期
关键词：
tuberculosis; HIV; antiretroviral treatment; immune; response; CD4 cell count; linear mixed model; SUB-SAHARAN AFRICA; ANTIRETROVIRAL TREATMENT PROGRAM; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; INCOME COUNTRIES; THERAPY; ADULTS; ACTIVATION; IMPACT; AIDS;
D O I：
10.1097/QAI.0b013e318288b39d
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied the immune response after starting anti-retroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/mL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.
引用
收藏
页码：142 / 145
页数：4
相关论文
共 50 条
  • [21] Survival of a large cohort of HIV-infected tuberculosis patients in the era of highly active antiretroviral treatment
    Catala, L.
    Orcau, A.
    de Olalla, P. Garcia
    Millet, J-P.
    Rodriguez-Mondragon, A.
    Cayla, J. A.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2011, 15 (02) : 263 - 269
  • [22] Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy
    Stuehler, Claudia
    Bernardini, Claudia
    Elzi, Luigia
    Stoeckle, Marcel
    Zimmerli, Stefan
    Furrer, Hansjakob
    Gunthard, Huldrych F.
    Leibundgut-Landmann, Salome
    Battegay, Manuel
    Khanna, Nina
    AIDS, 2016, 30 (12) : 1923 - 1933
  • [23] Alcohol use and non-adherence to antiretroviral therapy in HIV-infected patients in West Africa
    Jaquet, Antoine
    Ekouevi, Didier K.
    Bashi, Jules
    Aboubakrine, Maiga
    Messou, Eugene
    Maiga, Moussa
    Traore, Hamar Alassane
    Zannou, Marcel Djimon
    Guehi, Calixte
    Ba-Gomis, Franck Olivier
    Minga, Albert
    Allou, Gerard
    Eholie, Serge Paul
    Bissagnene, Emmanuel
    Sasco, Annie J.
    Dabis, Francois
    ADDICTION, 2010, 105 (08) : 1416 - 1421
  • [24] Renal dysfunction among HIV-infected patients starting antiretroviral therapy
    Msango, Leonard
    Downs, Jennifer A.
    Kalluvya, Samuel E.
    Kidenya, Benson R.
    Kabangila, Rodrick
    Johnson, Warren D., Jr.
    Fitzgerald, Daniel W.
    Peck, Robert N.
    AIDS, 2011, 25 (11) : 1421 - 1425
  • [25] Predictors of survival in HIV-infected tuberculosis patients
    Shafer, RW
    Bloch, AB
    Larkin, C
    Vasudavan, V
    Seligman, S
    Dehovitz, JD
    DiFerdinando, G
    Stoneburner, R
    Cauthen, G
    AIDS, 1996, 10 (03) : 269 - 272
  • [26] Risk of development of tuberculosis in HIV-infected patients
    Swaminathan, S
    Ramachandran, R
    Baskaran, G
    Paramasivan, CN
    Ramanathan, U
    Venkatesan, P
    Prabhakar, R
    Datta, M
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2000, 4 (09) : 839 - 844
  • [27] Treatment with adalimumab for severe immune reconstitution inflammatory syndrome in an HIV-infected patient presenting with cryptococcal meningitis
    Gaube, G.
    De Castro, N.
    Gueguen, A.
    Lascoux, C.
    Zagdanski, A. -M.
    Alanio, A.
    Molina, J. -M.
    MEDECINE ET MALADIES INFECTIEUSES, 2016, 46 (03): : 154 - 156
  • [28] Tuberculosis in HIV-infected patients in Croatia between 1986 and 2005
    Puljiz, Ivan
    Begovac, Josip
    COLLEGIUM ANTROPOLOGICUM, 2006, 30 : 53 - 58
  • [29] Vitamin A status of patients presenting with pulmonary tuberculosis and asymptomatic HIV-infected individuals, Dar es Salaam, Tanzania
    Mugusi, FM
    Rusizoka, O
    Habib, N
    Fawzi, W
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2003, 7 (08) : 804 - 807
  • [30] Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa
    Andrew D Kerkhoff
    Robin Wood
    Frank G Cobelens
    Ankur Gupta-Wright
    Linda-Gail Bekker
    Stephen D Lawn
    BMC Infectious Diseases, 14
12345