Immune Recovery After Starting ART in HIV-Infected Patients Presenting and Not Presenting With Tuberculosis in South Africa

被引：13
|
作者：
Schomaker, Michael [1 ]
Egger, Matthias [2 ]
Maskew, Mhairi [3 ]
Garone, Daniela [4 ]
Prozesky, Hans [5 ,6 ]
Hoffmann, Christopher J. [7 ,8 ]
Boulle, Andrew [1 ]
Fenner, Lukas [2 ,9 ,10 ]
机构：
[1] Univ Cape Town, Sch Publ Hlth & Family Med, CIDER, ZA-7925 Cape Town, South Africa
[2] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
[3] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med,Hlth Econ & Epidemiol Res Off, Johannesburg, South Africa
[4] Med Sans Frontieres, Khayelitsha ART Programme, Cape Town, South Africa
[5] Univ Stellenbosch, Dept Med, Div Infect Dis, Cape Town, South Africa
[6] Tygerberg Hosp, Cape Town, South Africa
[7] Aurum Inst, Johannesburg, South Africa
[8] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[9] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
[10] Univ Basel, Basel, Switzerland
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 63卷 / 01期
关键词：
tuberculosis; HIV; antiretroviral treatment; immune; response; CD4 cell count; linear mixed model; SUB-SAHARAN AFRICA; ANTIRETROVIRAL TREATMENT PROGRAM; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; INCOME COUNTRIES; THERAPY; ADULTS; ACTIVATION; IMPACT; AIDS;
D O I：
10.1097/QAI.0b013e318288b39d
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied the immune response after starting anti-retroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/mL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.
引用
收藏
页码：142 / 145
页数：4
相关论文
共 50 条
  • [1] Tuberculosis and the risk of opportunistic infections and cancers in HIV-infected patients starting ART in Southern Africa
    Fenner, Lukas
    Reid, Stewart E.
    Fox, Matthew P.
    Garone, Daniela
    Wellington, Maureen
    Prozesky, Hans
    Zwahlen, Marcel
    Schomaker, Michael
    Wandeler, Gilles
    Kancheya, Nzali
    Boulle, Andrew
    Wood, Robin
    Henostroza, German
    Egger, Matthias
    TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2013, 18 (02) : 194 - 198
  • [2] Intensive Tuberculosis Screening for HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa
    Bassett, Ingrid V.
    Wang, Bingxia
    Chetty, Senica
    Giddy, Janet
    Losina, Elena
    Mazibuko, Matilda
    Bearnot, Benjamin
    Allen, Jenny
    Walensky, Rochelle P.
    Freedberg, Kenneth A.
    CLINICAL INFECTIOUS DISEASES, 2010, 51 (07) : 823 - 829
  • [3] Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa
    Kerkhoff, Andrew D.
    Wood, Robin
    Cobelens, Frank G.
    Gupta-Wright, Ankur
    Bekker, Linda-Gail
    Lawn, Stephen D.
    BMC INFECTIOUS DISEASES, 2014, 14
  • [4] Frailty in HIV-Infected Adults in South Africa
    Pathai, Sophia
    Gilbert, Clare
    Weiss, Helen A.
    Cook, Colin
    Wood, Robin
    Bekker, Linda-Gail
    Lawn, Stephen D.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2013, 62 (01) : 43 - 51
  • [5] ENDOBRONCHIAL TUBERCULOSIS IN HIV-INFECTED PATIENTS
    CALPE, JL
    CHINER, E
    LARRAMENDI, CH
    AIDS, 1995, 9 (10) : 1159 - 1164
  • [6] Tuberculosis prevention in HIV-infected pregnant women in South Africa
    Martin, C. E.
    Black, V.
    SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE, 2012, (46) : 182 - 184
  • [7] Tuberculosis in HIV-infected patients:: a comprehensive review
    Aaron, L
    Saadoun, D
    Calatroni, I
    Launay, O
    Mémain, N
    Vincent, V
    Marchal, G
    Dupont, B
    Bouchaud, O
    Valeyre, D
    Lortholary, O
    CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (05) : 388 - 398
  • [8] Outcomes in HIV-infected patients who develop tuberculosis after starting antiretroviral treatment in Malawi
    Yu, J. K-L.
    Bong, C-N.
    Chen, S. C-C.
    Dzimadzi, R.
    Lu, D-Y.
    Makombe, S. D.
    Schouten, E. J.
    Kamoto, K.
    Harries, A. D.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2008, 12 (06) : 692 - 694
  • [9] Survival of HIV-infected patients after starting tuberculosis treatment: a prospective cohort study
    Maruza, M.
    Albuquerque, M. F. P. M.
    Braga, M. C.
    Barbosa, M. T. S.
    Byington, R.
    Coimbra, I.
    Moura, L. V.
    Batista, J. D. L.
    Diniz, G. T. N.
    Miranda-Filho, D. B.
    Lacerda, H. R.
    Rodrigues, L. C.
    Ximenes, R. A. A.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2012, 16 (05) : 618 - 624
  • [10] Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART
    Worodria, William
    Massinga-Loembe, Marguerite
    Mayanja-Kizza, Harriet
    Namaganda, Jane
    Kambugu, Andrew
    Manabe, Yukari C.
    Kestens, Luc
    Colebunders, Robert
    CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011,
12345