Synthesis of exfoliate bentonite/cellulose nanocomposite as a delivery system for Oxaliplatin drug with enhanced loading and release properties; cytotoxicity and pharmacokinetic studies

被引：9

作者：

Abukhadra, Mostafa R. ^{[1
,2
]}

Mohamed, Aya S. ^{[2
,3
]}

El-Sherbeeny, Ahmed M. ^{[4
]}

Nadeem, Ahmed ^{[5
]}

Ahmad, Sheikh F. ^{[5
]}

机构：

[1] Beni Suef Univ, Fac Sci, Geol Dept, Bani Suwayf, Egypt

[2] Beni Suef Univ, Fac Sci, Geol Dept, Mat Technol & Their Applicat Lab, Bani Suwayf, Egypt

[3] Beni Suef Univ, Fac Postgrad Studies Adv Sci, Dept Environm & Ind Dev, Bani Suwayf, Egypt

[4] King Saud Univ, Coll Engn, Ind Engn Dept, POB 800, Riyadh 11421, Saudi Arabia

[5] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh, Saudi Arabia

来源：

CHEMICAL PHYSICS LETTERS | 2020年 / 755卷

关键词：

Bentonite; Exfoliation; Cellulose; Oxaliplatin drug; Cytotoxicity; Pharmacokinetic; EQUILIBRIUM; ADSORPTION; CELLULOSE; DYE;

D O I：

10.1016/j.cplett.2020.137818

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Exfoliated bentonite/cellulose nanocomposite was synthesized as a carrier for Oxaliplatin drug. The composite is of 587.4 mg g(-1) loading capacity and the loading mechanism fitted with Pseudo-first order kinetic and Langmuir isotherm models. The composite shows continuous and slow release profile for 100 h with 83.3% (pH 5.5) and 93.4% (pH 7.4) as maximum releasing percentages. The diffusion exponents from the kinetic models (0.58 (pH 7.4) and 0.79 (pH 5.5)) suggested erosion and diffusion release mechanisms. The composite is of 94.3% cell viability for the normal cells and 23% for the colorectal cancer cells.

引用

页数：8

共 32 条

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