The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology

被引：105

作者：

Nemoto, K

Ohnishi, T

Mori, T

Moriguchi, Y

Hashimoto, R

Asada, T

Kunugi, H

机构：

[1] Natl Ctr Hosp Mental Nervous & Muscular Disorders, Natl Ctr Neurol & Psychiat, Dept Radiol, Tokyo 1878551, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Invest Radiol, Osaka 5658565, Japan

[3] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Tokyo 1878551, Japan

[4] Univ Tsukuba, Inst Clin Med, Dept Neuropsychiat, Tsukuba, Ibaraki 3058575, Japan

[5] Ibaraki Prefectural Tomobe Hosp, Dept Psychiat, Tomobe, Ibaraki 3091717, Japan

来源：

NEUROSCIENCE LETTERS | 2006年 / 397卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

brain-derived neurotrophic factor; Val66Met polymorphism; magnetic resonance imaging; voxel-based morphometry; dorsolateral prefrontal cortex; aging;

D O I：

10.1016/j.neulet.2005.11.067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effects of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on age-associated changes of brain morphology in 109 Japanese healthy subjects using MRI with optimized voxel-based morphometry technique. A significant age-related volume reduction was found in the dorsolateral prefrontal cortices (DLPFC), anterior cingulate cortices, and temporal and parietal cortices in all subjects. Further analysis revealed a significantly negative correlation between age and the volume of the bilateral DLPFC only in the Met-BDNF carriers, and a significant interaction between the polymorphism and age-associated volume changes in the bilateral DLPFC. Furthermore, Met-carriers showed a significant interaction (p < 0.0001) between the gender and the genotype on the gray matter volume in the DLPFC, and female Met-carriers showed more widespread age-associated volume reduction in DLPFC than male Met-carriers. Our data suggest that the Val66Met polymorphism may impact on age-related changes of the brain, which might be associated with the functional variance of neuroprotective effects of the BDNF. Furthermore, we suggest that genotype effects of the BDNF gene on brain morphology might differ in female from in male. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：25 / 29

页数：5

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