Thrombocytosis and Hepatocellular Carcinoma

被引：68

作者：

Carr, Brian I. ^{[1
,2
]}

Guerra, Vito ^{[1
,2
]}

机构：

[1] Natl Inst Digest Dis, Dept Nutr Carcinogenesis, IRCCS S de Bellis, I-70013 Castellana Grotte, BA, Italy

[2] Natl Inst Digest Dis, Dept Epidemiol, IRCCS S de Bellis, I-70013 Castellana Grotte, BA, Italy

来源：

DIGESTIVE DISEASES AND SCIENCES | 2013年 / 58卷 / 06期

关键词：

HCC; Size; Thrombocytosis; Portal vein thrombosis; HEPATITIS-B-VIRUS; GROWTH-FACTOR; LIVER; THROMBOPOIETIN; PLATELETS; HEPATOBLASTOMA; CIRRHOSIS; DISEASE; RISK; PDGF;

D O I：

10.1007/s10620-012-2527-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Thrombocytopenia has been reported to be both a risk factor for hepatocellular carcinoma (HCC) development as well as a prognostic factor. Many HCCs also occur in presence of normal platelets. Aim To examine a cohort of HCC patients with associated thrombocytosis. Methods Records were examined of a cohort of 634 biopsy-proven and randomly presenting HCC patients without thrombocytopenia. Results In the total cohort, 52 patients were identified with thrombocytosis (platelet levels >400 x10(9)/L) and compared with 582 patients with normal platelet values. The average tumor sizes were 13.1 versus 8.8 cm (p < 0.0001), and their total average bilirubin levels were 0.9 versus 1.5 (p = 0.02), comparing thrombocytosis patients versus normal platelet count HCC patients. These differences were even more pronounced in patients with HCC sizes >5 cm. Thrombocytosis patients were younger and had less cirrhosis, but similar percent with hepatitis B or C or alcohol consumption. Conclusion Thrombocytosis in association with HCC occurs in patients with larger tumor sizes and better liver function.

引用

页码：1790 / 1796

页数：7

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