Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March-October 2019

被引:13
作者
Roosa, Kimberlyn [1 ]
Tariq, Amna [1 ]
Yan, Ping [2 ]
Hyman, James M. [3 ]
Chowell, Gerardo [1 ,4 ]
机构
[1] Georgia State Univ, Sch Publ Hlth, Dept Populat Hlth Sci, Atlanta, GA 30303 USA
[2] Publ Hlth Agcy Canada, Infect Dis Prevent & Control Branch, Ottawa, ON, Canada
[3] Tulane Univ, Ctr Computat Sci, Dept Math, New Orleans, LA 70118 USA
[4] NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA
关键词
real-time forecast; phenomenological models; Ebola; Democratic Republic of the Congo; uncertainty quantification; reporting delay; PREDICTION; DISEASE; DELAYS;
D O I
10.1098/rsif.2020.0447
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The 2018-2020 Ebola outbreak in the Democratic Republic of the Congo is the first to occur in an armed conflict zone. The resulting impact on population movement, treatment centres and surveillance has created an unprecedented challenge for real-time epidemic forecasting. Most standard mathematical models cannot capture the observed incidence trajectory when it deviates from a traditional epidemic logistic curve. We fit seven dynamic models of increasing complexity to the incidence data published in the World Health Organization Situation Reports, after adjusting for reporting delays. These models include a simple logistic model, a Richards model, an endemic Richards model, a double logistic growth model, a multi-model approach and two sub-epidemic models. We analyse model fit to the data and compare real-time forecasts throughout the ongoing epidemic across 29 weeks from 11 March to 23 September 2019. We observe that the modest extensions presented allow for capturing a wide range of epidemic behaviour. The multi-model approach yields the most reliable forecasts on average for this application, and the presented extensions improve model flexibility and forecasting accuracy, even in the context of limited epidemiological data.
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页数:12
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