Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review

被引：15
作者：
Cao, Zaizai [1 ,2 ,3 ]
Gao, Jinjian [1 ,2 ,3 ]
Huang, Saiyu [1 ,2 ,3 ]
Xiang, Haijie [1 ,2 ,3 ]
Zhang, Chuqin [1 ,2 ,3 ]
Zheng, Bo [1 ,2 ,3 ]
Zhan, Xiang [1 ,2 ,3 ]
Chen, Ruru [1 ,2 ,3 ]
Chen, Bobei [1 ,2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Otolaryngol, Coll West Rd 109, Wenzhou 325027, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Coll West Rd 109, Wenzhou 325027, Peoples R China
[3] Wenzhou Med Univ, Sch Med 2, Wenzhou, Peoples R China
来源：
AUDIOLOGY AND NEURO-OTOLOGY | 2019年 / 24卷 / 01期
关键词：
Sudden sensorineural hearing loss; Genetic polymorphisms; Susceptibility; Systematic review; Single nucleotide polymorphisms; FACTOR-V-LEIDEN; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; PHOSPHODIESTERASE 4D GENE; ESTROGEN-RECEPTOR-ALPHA; RISK-FACTORS; ISCHEMIC-STROKE; MYOCARDIAL-INFARCTION; C677T POLYMORPHISM; MENIERES-DISEASE; ASSOCIATION;
D O I：
10.1159/000497032
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Background: Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. KeyMessage: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL. Summary: Although a great number of studies support that polymorphisms in genes are associated with susceptibility to SSNHL, we need large multicenter studies, which evaluate multiple single nucleotide polymorphisms in SSNHL patients, to find real genetic risk factors for susceptibility to SSNHL. This is very helpful in designing more effective prevention and treatment strategies for patients with SSNHL. (C) 2019 S. Karger AG, Basel
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页码：8 / 19
页数：12
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