Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities

被引：43

作者：

Kong, Xianglan ^{[1
]}

Ma, Xinhua ^{[1
]}

Xie, Yunying ^{[2
,3
]}

Cai, Shengxin ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Gu, Qianqun ^{[1
]}

Li, Dehai ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China

[2] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 06期

关键词：

Sponge-derived fungus; Secondary metabolites; Naphtho-gamma-pyrones; Diphenyl ethers; Antitubercular activity; NAPHTHO-GAMMA-PYRONES; TUBERCULOSIS; METABOLITES; DERIVATIVES;

D O I：

10.1007/s12272-013-0077-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In our screening for antitubercular agents, five naphtho-gamma-pyrones including two new naphtho-gamma-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B-2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 mu g/mL.

引用

页码：739 / 744

页数：6

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