Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities

被引：43
作者：
Kong, Xianglan [1 ]
Ma, Xinhua [1 ]
Xie, Yunying [2 ,3 ]
Cai, Shengxin [1 ]
Zhu, Tianjiao [1 ]
Gu, Qianqun [1 ]
Li, Dehai [1 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
[2] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 06期
关键词：
Sponge-derived fungus; Secondary metabolites; Naphtho-gamma-pyrones; Diphenyl ethers; Antitubercular activity; NAPHTHO-GAMMA-PYRONES; TUBERCULOSIS; METABOLITES; DERIVATIVES;
D O I：
10.1007/s12272-013-0077-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In our screening for antitubercular agents, five naphtho-gamma-pyrones including two new naphtho-gamma-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B-2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 mu g/mL.
引用
收藏
页码：739 / 744
页数：6
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