Epicardial adipose tissue expression of adiponectin is lower in patients with hypertension

被引：66

作者：

Teijeira-Fernandez, E. ^{[1
]}

Eiras, S. ^{[1
]}

Grigorian-Shamagian, L.

Fernandez, A. ^{[2
]}

Adrio, B. ^{[2
]}

Gonzalez-Juanatey, J. R. ^{[1
]}

机构：

[1] Hosp Clin Univ, Dept Cardiol, Unit Cellular & Mol Res Cardiol, Santiago De Compostela 15706, Spain

[2] Hosp Clin Univ, Dept Heart Surg, Santiago De Compostela 15706, Spain

来源：

JOURNAL OF HUMAN HYPERTENSION | 2008年 / 22卷 / 12期

关键词：

adiponectin; adipose tissue; blood pressure; hypertension;

D O I：

10.1038/jhh.2008.75

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Low plasma adiponectin levels are related to a higher risk of development of metabolic and cardiovascular disorders, including hypertension ( HT). To date, there have been no studies supporting the relationship between epicardial adipose tissue (EAT) expression of adiponectin and HT. We collected samples of EAT from 116 patients undergoing elective cardiac surgery, mostly for coronary artery bypass grafting (n = 54), valve surgery (n = 49) or both (n = 12). Samples of subcutaneous adipose tissue (SAT) were harvested from 85 patients. After RNA isolation, the expression of adiponectin was analysed by real-time retrotranscriptase (RT)-PCR. Baseline clinical data were obtained from medical records. The diagnosis of HT was established mostly by the patients' general physicians following current guidelines. We included 84 hypertensive and 32 non-hypertensive patients. Mean (+/- s.d.)age was 70.3 +/- 7.9 years. EAT expression levels of adiponectin

引用

页码：856 / 863

页数：8

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