共 59 条
G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation
被引:75
作者:

Gavi, S
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机构:
SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Pharmacol, Stony Brook, NY 11794 USA SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Pharmacol, Stony Brook, NY 11794 USA

Shumay, E
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h-index: 0
机构: SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Pharmacol, Stony Brook, NY 11794 USA

Wang, HY
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h-index: 0
机构: SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Pharmacol, Stony Brook, NY 11794 USA

Malbon, CC
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h-index: 0
机构: SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Pharmacol, Stony Brook, NY 11794 USA
机构:
[1] SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Pharmacol, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Diabet & Metab Dis Res Ctr,Dept Physiol & Biophys, Stony Brook, NY 11794 USA
关键词:
D O I:
10.1016/j.tem.2006.01.006
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
G-protein-coupled receptors and protein tyrosine kinases represent two prominent pathways for cellular signaling. As our knowledge of cell signaling pathways mediated by the superfamily of G-protein-coupled receptors and the smaller family of receptor tyrosine kinases expands, so does our appreciation of how these two major signaling platforms share information and modulate each other, otherwise termed 'cross-talk'. Cross-talk between G-protein-coupled receptors and tyrosine kinases can occur at several levels, including the receptor-to-receptor level, and at crucial downstream points (e.g. phosphatidylinositol-3-kinase, Akt/protein kinase B and the mitogen-activated protein kinase cascade). Regulation of G-protein-coupled receptors by non-receptor tyrosine kinases, such as Src family members, also operates in signaling. A broader understanding of how G-protein-coupled receptors and tyrosine kinases cross-talk reveals new insights into signaling modalities in both health and disease.
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页码:46 / 52
页数:7
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共 59 条
- [1] Sensitivity of rabbit aorta and mesenteric artery to norepinephrine: role of tyrosine kinases[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 476 (03) : 201 - 209Adegunloye, BJ论文数: 0 引用数: 0 h-index: 0机构: Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USASu, XL论文数: 0 引用数: 0 h-index: 0机构: Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USACamper, EV论文数: 0 引用数: 0 h-index: 0机构: Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USAMoreland, RS论文数: 0 引用数: 0 h-index: 0机构: Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA
- [2] A role for tyrosine phosphorylation in the regulation and sensitization of adenylate cyclase by melatonin[J]. FASEB JOURNAL, 2000, 14 (11) : 1619 - 1628Barrett, P论文数: 0 引用数: 0 h-index: 0机构: Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst, Aberdeen AB21 9SB, ScotlandChoi, WS论文数: 0 引用数: 0 h-index: 0机构: Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst, Aberdeen AB21 9SB, ScotlandMorris, M论文数: 0 引用数: 0 h-index: 0机构: Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst, Aberdeen AB21 9SB, ScotlandMorgan, P论文数: 0 引用数: 0 h-index: 0机构: Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst, Aberdeen AB21 9SB, Scotland
- [3] Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor[J]. BIOCHEMICAL JOURNAL, 2001, 360 : 77 - 85Bisotto, S论文数: 0 引用数: 0 h-index: 0机构: McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, Canada McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, CanadaFixman, ED论文数: 0 引用数: 0 h-index: 0机构: McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, Canada McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, Canada
- [4] Direct binding of activated c-Src to the β3-adrenergic receptor is required for MAP kinase activation[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (49) : 38131 - 38134Cao, WH论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USALuttrell, LM论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USAMedvedev, AV论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USAPierce, KL论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USADaniel, KW论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USADixon, TM论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USALefkowitz, RJ论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USACollins, S论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA
- [5] Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (02) : 685 - 688Daaka, Y论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USALuttrell, LM论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USAAhn, S论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USADella Rocca, GJ论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USAFerguson, SSG论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USACaron, MG论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USALefkowitz, RJ论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USA Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USA
- [6] Insulin induces heterologous desensitization of G protein-coupled receptor and insulin-like growth factor I signaling by downregulating β-arrestin-1[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (17) : 6272 - 6285Dalle, S论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAImamura, T论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USARose, DW论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAWorrall, DS论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAUgi, S论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAHupfeld, CJ论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAOlefsky, JM论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA
- [7] Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (18) : 16107 - 16116Derrien, A论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USAZheng, B论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USAOsterhout, JL论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USAMa, YC论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USAMilligan, G论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USAFarquhar, MG论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USADruey, KM论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USA
- [8] RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) : 48532 - 48538Derrien, A论文数: 0 引用数: 0 h-index: 0机构: NIH, Mol Signal Transduct Sect, Lab Allerg Dis, Rockville, MD 20852 USA NIH, Mol Signal Transduct Sect, Lab Allerg Dis, Rockville, MD 20852 USADruey, KM论文数: 0 引用数: 0 h-index: 0机构: NIH, Mol Signal Transduct Sect, Lab Allerg Dis, Rockville, MD 20852 USA NIH, Mol Signal Transduct Sect, Lab Allerg Dis, Rockville, MD 20852 USA
- [9] c-Src tyrosine kinase binds the β2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) : 13240 - 13247Fan, GF论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Dept Mol Pharmacol, Med Ctr, Diabet & Metabol Dis Res Program, Stony Brook, NY 11794 USAShumay, E论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Dept Mol Pharmacol, Med Ctr, Diabet & Metabol Dis Res Program, Stony Brook, NY 11794 USAMalbon, CC论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Dept Mol Pharmacol, Med Ctr, Diabet & Metabol Dis Res Program, Stony Brook, NY 11794 USAWang, HY论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Dept Mol Pharmacol, Med Ctr, Diabet & Metabol Dis Res Program, Stony Brook, NY 11794 USA
- [10] The 15-amino acid motif of the C terminus of the β2-adrenergic receptor is sufficient to confer insulin-stimulated counterregulation to the β1-adrenergic receptor[J]. ENDOCRINOLOGY, 2005, 146 (01) : 450 - 457Gavi, S论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Univ Med Ctr, Dept Mol Pharmacol, Stony Brook, NY 11794 USAYin, DZ论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Univ Med Ctr, Dept Mol Pharmacol, Stony Brook, NY 11794 USAShumay, E论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Univ Med Ctr, Dept Mol Pharmacol, Stony Brook, NY 11794 USAWang, HY论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Univ Med Ctr, Dept Mol Pharmacol, Stony Brook, NY 11794 USAMalbon, CC论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Univ Med Ctr, Dept Mol Pharmacol, Stony Brook, NY 11794 USA