One-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed three-component cascade annulation of amines, alkyne esters and terminal alkynes

被引：8
作者：
Li, Yunlan [1 ]
Zhang, Qiurui [1 ]
Xu, Xuefeng [1 ]
Zhang, Xu [1 ]
Yang, Yurong [2 ,3 ,4 ]
Yi, Wei [2 ,3 ,4 ]
机构：
[1] Nanyang Normal Univ, Sch Chem & Pharmacony Engn, Nanyang 473061, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 14期
基金：
中国国家自然科学基金;
关键词：
AgOTf catalyst; Amines; Alkyne esters; Terminal alkynes; 2,4-Disubstituted quinolines; C-H ACTIVATION; REGIOSELECTIVE SYNTHESIS; OXIDATIVE ANNULATION; TANDEM SYNTHESIS; DERIVATIVES; FUNCTIONALIZATION; ACCESS; ALDEHYDES; ANILINES; DIARYLIODONIUMS;
D O I：
10.1016/j.tetlet.2019.03.003
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Described herein is a new and general method for one-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed [3 + 1 + 2] annulation of simple amines, alkyne esters and terminal alkynes. The versatile transformation might initiate with the facile formation of the enamine species with the feature of good to excellent yields, exclusive regioselectivity, and excellent substrate/functional group tolerance. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：965 / 970
页数：6
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