Synthesis and biological evaluation of some novel thiadiazole-benzofuran hybrids as potential antitumor agents

被引：14
作者：
Abdelhamid, Abdou O. [1 ]
Gomha, Sobhi M. [1 ]
Abdelrehem, Nadia A. [1 ]
Shalaby, Ahmed M. [2 ]
Kandeel, Sahar M. [3 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] Natl Res Ctr, Dept Peptide Chem, Cairo, Egypt
[3] Natl Res Ctr, Dept Nat Cpds, Cairo, Egypt
来源：
SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 06期
关键词：
1,3,4-Thiadiazoles; antitumor activity; benzofuran; hydrazonoyl halides; khellinone; ANTICANCER ACTIVITY; 1,3,4-THIADIAZOLE DERIVATIVES; GREEN SYNTHESIS; BASIC CATALYST; THIAZOLES; HETEROCYCLES; IMIDAZOLE; UTILITY; MOIETY; 1,3-THIAZINES;
D O I：
10.1080/00397911.2017.1416637
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two series of novel 1,3,4-thiadiazole-benzofuran and 1,3,4-thiadiazole-furochromene derivatives were synthesized through heterocyclization of alkyl 2-(1-(6-hydroxy-4,7-dimethoxybenzofuran-5-yl)ethylidene)hydrazine-1-carbodithioate 3a-f and 2-(1-(5-methoxy-8-methyl-2,6-dioxo-2,6-dihydropyrano[3,2-g]chromen-3-yl)ethylidene)hydrazinecarbothioamide 9a,b with various hydrazonoyl halides, respectively. The structure of the newly synthesized products was elucidated through elemental analysis, spectral data and alternative routes whenever possible. Ten new compounds were evaluated for their anticancer activity against the human breast carcinoma (MCF-7) cell lines in comparison with reference doxorubicin using MTT assay. The results showed that some new compounds have promising anticancer activity. [GRAPHICS] .
引用
收藏
页码：677 / 684
页数：8
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