Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population

被引：11

作者：

Xie, Liang ^{[1
,2
,3
]}

Gong, Yuan-ying ^{[1
,3
]}

Lian, Shi-gang ^{[4
]}

Yang, Juan ^{[4
]}

Yang, Ya ^{[5
]}

Gao, Shou-jun ^{[6
]}

Xu, Liang-you ^{[6
]}

Zhang, Ya-ping ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China

[2] Yunnan Univ, Lab Conservat & Utilizat Bioresource, Kunming 650091, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[4] Peoples Hosp Dujiangyan City, Dujiangyan 611830, Peoples R China

[5] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech & Learning &, Kunming 650223, Peoples R China

[6] Dujiangyan Longev Res Ctr, Dujiangyan 611830, Peoples R China

来源：

EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Longevity; IGF-1; Association study; SNPs; Han Chinese population;

D O I：

10.1016/j.exger.2008.08.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential role of the promoter region variation of IGF-1 gene in longevity, we investigated 485 longevity subjects and 392 younger individuals from Dujiangyan, China. By sequencing about 2.5 kb (kilo base pairs) upstream the transcription start site of exon 1 of the IGF-1 gene in 30 individuals from both groups respectively, we acquired three previously described SNPs (-439T/A (rs2288377), -541T/C (rs5742612) and -1246C/T (rs35767)). We examined the association between these three SNPs and longevity by comparing the distribution of genotypes, alleles, and haplotypes in both the longevity and control groups. None of these variants were found to be associated with longevity. Our results suggest that there is no association between SNPs in the promoter region of IGF-1 gene and longevity in the Han Chinese population. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：962 / 965

页数：4

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