Multimodal Pain Management in Veterinary Medicine: The Physiologic Basis of Pharmacologic Therapies

被引：95
作者：
Lamont, Leigh A. [1 ]
机构：
[1] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Compan Anim, Charlottetown, PE C1A 4P3, Canada
来源：
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE | 2008年 / 38卷 / 06期
关键词：
Multimodal analgesia; Nociception; Pain;
D O I：
10.1016/j.cvsm.2008.06.005
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Multimodal analgesia refers to the practice of combining multiple analgesic drug classes or techniques to target different points along the pain pathway in an effort to improve analgesia. This strategy requires an understanding of pain physiology and pathophysiology so pharmacologic interventions can be tailored to meet the needs of the patient. This article reviews the physiologic basis of pain as it relates to analgesic treatments and also introduces new developments in molecular biology that may guide analgesic drug development in the future.
引用
收藏
页码：1173 / +
页数：15
相关论文
共 56 条
[21]   Dexmedetomidine injection into the locus ceruleus produces antinociception [J].
Guo, TZ ;
Jiang, JY ;
Buttermann, AE ;
Maze, M .
ANESTHESIOLOGY, 1996, 84 (04) :873-881
[22]   Could chronic pain and spread of pain sensation be induced and maintained by glial activation? [J].
Hansson, E. .
ACTA PHYSIOLOGICA, 2006, 187 (1-2) :321-327
[23]   Novel class of pain drugs based on antagonism of NGF [J].
Hefti, FF ;
Rosenthal, A ;
Walicke, PA ;
Wyatt, S ;
Vergara, G ;
Shelton, DL ;
Davies, AM .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 27 (02) :85-91
[24]   Trk receptors: Roles in neuronal signal transduction [J].
Huang, EJ ;
Reichardt, LF .
ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :609-642
[25]  
Hutchinson Mark R, 2007, ScientificWorldJournal, V7, P98
[26]   Clinical pharmacology of opioids for pain [J].
Inturrisi, CE .
CLINICAL JOURNAL OF PAIN, 2002, 18 (04) :S3-S13
[27]   RESPONSES OF NEURONS IN THE LATERAL CERVICAL NUCLEUS OF THE CAT TO NOXIOUS CUTANEOUS STIMULATION [J].
KAJANDER, KC ;
GIESLER, GJ .
JOURNAL OF NEUROPHYSIOLOGY, 1987, 57 (06) :1686-1704
[28]   Nerve growth factor activates mast cells through the collaborative interaction with lysophosphatidylserine expressed on the membrane surface of activated platelets [J].
Kawamoto, K ;
Aoki, J ;
Tanaka, A ;
Itakura, A ;
Hosono, H ;
Arai, H ;
Kiso, Y ;
Matsuda, H .
JOURNAL OF IMMUNOLOGY, 2002, 168 (12) :6412-6419
[29]   Regulation of the mouse epithelial Ca2+ channel TRPV6 by the Ca2+-sensor calmodulin [J].
Lambers, TT ;
Weidema, AF ;
Nilius, B ;
Hoenderop, JGJ ;
Bindels, RJM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (28) :28855-28861
[30]  
Levine JD, 1999, TXB PAIN, P59
123456