Multimodal Pain Management in Veterinary Medicine: The Physiologic Basis of Pharmacologic Therapies

被引:91
作者
Lamont, Leigh A. [1 ]
机构
[1] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Compan Anim, Charlottetown, PE C1A 4P3, Canada
关键词
Multimodal analgesia; Nociception; Pain;
D O I
10.1016/j.cvsm.2008.06.005
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Multimodal analgesia refers to the practice of combining multiple analgesic drug classes or techniques to target different points along the pain pathway in an effort to improve analgesia. This strategy requires an understanding of pain physiology and pathophysiology so pharmacologic interventions can be tailored to meet the needs of the patient. This article reviews the physiologic basis of pain as it relates to analgesic treatments and also introduces new developments in molecular biology that may guide analgesic drug development in the future.
引用
收藏
页码:1173 / +
页数:15
相关论文
共 56 条
  • [1] TREK-1, a K+ channel involved in polymodal pain perception
    Alloui, Abdelkrim
    Zimmermann, Katharina
    Mamet, Julien
    Duprat, Fabrice
    Noel, Jacques
    Chemin, Jean
    Guy, Nicolas
    Blondeau, Nicolas
    Voilley, Nicolas
    Rubat-Coudert, Catherine
    Borsotto, Marc
    Romey, Georges
    Heurteaux, Catherine
    Reeh, Peter
    Eschalier, Alain
    Lazdunski, Michel
    [J]. EMBO JOURNAL, 2006, 25 (11) : 2368 - 2376
  • [2] Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2
    Amaya, F
    Decosterd, I
    Samad, TA
    Plumpton, C
    Tate, S
    Mannion, RJ
    Costigan, M
    Woolf, CJ
    [J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (04) : 331 - 342
  • [3] [Anonymous], [No title captured]
  • [4] Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Bandell, M
    Story, GM
    Hwang, SW
    Viswanath, V
    Eid, SR
    Petrus, MJ
    Earley, TJ
    Patapoutian, A
    [J]. NEURON, 2004, 41 (06) : 849 - 857
  • [5] Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
    Blanpied, TA
    Clarke, RJ
    Johnson, JW
    [J]. JOURNAL OF NEUROSCIENCE, 2005, 25 (13) : 3312 - 3322
  • [6] Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model
    Brown, DC
    Iadarola, MJ
    Perkowski, SZ
    Erin, H
    Shofer, F
    Laszlo, KJ
    Olah, Z
    Mannes, AJ
    [J]. ANESTHESIOLOGY, 2005, 103 (05) : 1052 - 1059
  • [7] Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through α2-adrenergic receptors
    Budai, D
    Harasawa, I
    Fields, HL
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (05) : 2244 - 2254
  • [8] A capsaicin-receptor homologue with a high threshold for noxious heat
    Caterina, MJ
    Rosen, TA
    Tominaga, M
    Brake, AJ
    Julius, D
    [J]. NATURE, 1999, 398 (6726) : 436 - 441
  • [9] The roles of sodium channels in nociception: Implications for mechanisms of pain
    Cummins, Theodore R.
    Sheets, Patrick L.
    Waxman, Stephen G.
    [J]. PAIN, 2007, 131 (03) : 243 - 257
  • [10] The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia
    Curros-Criado, M. Mar
    Herrero, Juan F.
    [J]. JOURNAL OF NEUROINFLAMMATION, 2007, 4 (1)