Isatin Derivatives Containing Sterically Hindered Phenolic Fragment and Water-Soluble Acyl Hydrazones on Their Basis: Synthesis and Antimicrobial Activity

被引：23

作者：

Bogdanov, A. V. ^{[1
]}

Zaripova, I. F. ^{[2
]}

Voloshina, A. D. ^{[1
]}

Strobykina, A. S. ^{[1
]}

Kulik, N. V. ^{[1
]}

Bukharov, S. V. ^{[2
]}

Mironov, V. F. ^{[1
]}

机构：

[1] Russian Acad Sci, Kazan Sci Ctr, AE Arbuzov Inst Organ & Phys Chem, Ul Akad Arbuzova 8, Kazan 420088, Tatarstan, Russia

[2] Kazan Natl Res Technol Univ, Kazan, Tatarstan, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

isatin; phenolic fragment; hydrazides; hydrazones; antimicrobial activity; SELECTIVE NONPEPTIDE INHIBITORS; IN-VITRO; ANTICANCER ACTIVITIES; PRIVILEGED STRUCTURES; CASPASE-3; ACTIVATION; APOPTOSIS; DESIGN; AGENTS; ANALOGS; POTENT;

D O I：

10.1134/S1070363218010097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation reactions of isatin derivatives with 3,5-di(tert-butyl)-4-hydroxybenzyl acetate and the Girard's reagent T has afforded a series of novel water-soluble isatin-3-acyl hydrazones containing a sterically hindered phenolic fragment in position 1 of the heterocycle; antimicrobial activity of the products has been estimated. It has been shown that the isatin derivatives with bromine or methoxy substituent in the benzo fragment as well as the acyl hydrazones containing 5-methyl or 5-ethyl group are the most active against Staphylococcus aureus and Bacillus cereus.

引用

页码：57 / 67

页数：11

共 35 条

[1] Isatin Derivatives Containing Sterically Hindered Phenolic Fragment and Water-Soluble Acyl Hydrazones on Their Basis: Synthesis and Antimicrobial Activity
A. V. Bogdanov
I. F. Zaripova
A. D. Voloshina
A. S. Strobykina
N. V. Kulik
S. V. Bukharov
V. F. Mironov
Russian Journal of General Chemistry, 2018, 88 : 57 - 67
[2] Sterically Hindered Phenolic Isatin Derivatives Containing a DABCO Fragment: Synthesis and Antimicrobial Activity Testing
A. V. Bogdanov
A. D. Voloshina
A. P. Lyubina
S. K. Amerkhanova
T. V. Glukhareva
V. F. Mironov
Russian Journal of Organic Chemistry, 2022, 58 : 1067 - 1075
[3] Sterically Hindered Phenolic Isatin Derivatives Containing a DABCO Fragment: Synthesis and Antimicrobial Activity Testing
Bogdanov, A. V.
Voloshina, A. D.
Lyubina, A. P.
Amerkhanova, S. K.
Kalinina, T. A.
Glukhareva, T. V.
Mironov, V. F.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (08) : 1067 - 1075
[4] Synthesis and Antimicrobial Study of Novel 1-Benzylated Water-Soluble Isatin-3-hydrazones
Bogdanov, Andrei V.
Zaripova, Ilyuza F.
Voloshina, Alexandra D.
Sapunova, Anastasia S.
Kulik, Natalia V.
Voronina, Julia K.
Mironov, Vladimir F.
CHEMISTRY & BIODIVERSITY, 2018, 15 (06)
[5] Effect of the Cationic Moiety on the Antimicrobial Activity of Sterically Hindered Isatin 3-Hydrazone Derivatives
Bogdanov, A. V.
Kadomtseva, M. E.
Bukharov, S. V.
Voloshina, A. D.
Mironov, V. F.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (03) : 555 - 558
[6] Effect of the Cationic Moiety on the Antimicrobial Activity of Sterically Hindered Isatin 3-Hydrazone Derivatives
A. V. Bogdanov
M. E. Kadomtseva
S. V. Bukharov
A. D. Voloshina
V. F. Mironov
Russian Journal of Organic Chemistry, 2020, 56 : 555 - 558
[7] Synthesis and antimicrobial activity evaluation of some novel water-soluble isatin-3-acylhydrazones
Bogdanov, Andrei V.
Zaripova, Ilyuza F.
Voloshina, Alexandra D.
Strobykina, Anastasia S.
Kulik, Natalia V.
Bukharov, Sergey V.
Voronina, Julia K.
Khamatgalimov, Ayrat R.
Mironov, Vladimir F.
MONATSHEFTE FUR CHEMIE, 2018, 149 (01): : 111 - 117
[8] Synthesis of sterically hindered phenol-containing phosphorylated isatin derivatives
Oludina, Yu. N.
Bukharov, S. V.
Burilov, A. R.
Tagasheva, R. G.
Syakaev, V. V.
Musin, R. Z.
Akhmetova, E. F.
Nugumanova, G. N.
RUSSIAN CHEMICAL BULLETIN, 2014, 63 (01) : 115 - 117
[9] Synthesis of sterically hindered phenol-containing phosphorylated isatin derivatives
Yu. N. Oludina
S. V. Bukharov
A. R. Burilov
R. G. Tagasheva
V. V. Syakaev
R. Z. Musin
E. F. Akhmetova
G. N. Nugumanova
Russian Chemical Bulletin, 2014, 63 : 115 - 117
[10] On the Effect of the Nature of Substituents on the Antimicrobial Activity of Water-Soluble Acylhydrazones on the Isatin Scaffold
Bogdanov, A., V
Voloshina, A. D.
Khamatgalimov, A. R.
Terekhova, N., V
Mironov, V. F.
DOKLADY CHEMISTRY, 2020, 494 (01) : 136 - 140

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