A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium

被引：57

作者：

Oppedal, Ketil ^{[1
,2
]}

Ferreira, Daniel ^{[3
]}

Cavallin, Lena ^{[4
,5
]}

Lemstra, Afina W. ^{[6
,7
]}

ten Kate, Mara ^{[6
,7
]}

Padovani, Alessandro ^{[8
]}

Rektorova, Irena ^{[9
,10
]}

Bonanni, Laura ^{[11
,12
]}

Wahlund, Lars-Olof ^{[3
]}

Engedal, Knut ^{[13
,14
]}

Nobili, Flavio ^{[15
,16
]}

Kramberger, Milica ^{[17
]}

Taylor, John-Paul ^{[18
]}

Hort, Jakub n ^{[19
,20
,21
]}

Snaedal, Jon ^{[22
]}

Blanc, Frederic ^{[23
,24
,25
,26
]}

Walker, Zuzana ^{[27
]}

Antonini, Angelo ^{[28
,29
]}

Westman, Eric ^{[3
,30
]}

Aarsland, Dag ^{[1
,31
]}

机构：

[1] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[2] Stavanger Univ Hosp, Dept Radiol, Stavanger, Norway

[3] Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[4] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[5] Karolinska Univ Hosp, Dept Radiol, Stockholm, Sweden

[6] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[7] Vrije Univ Amsterdam Med Ctr, Alzheimerctr, Amsterdam, Netherlands

[8] Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy

[9] Masaryk Univ, Fac Med, St Annes Hosp, Dept Neurol 1, Brno, Czech Republic

[10] Masaryk Univ, CEITEC, Brno, Czech Republic

[11] Univ G Annunzio Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[12] Univ G Annunzio Chieti Pescara, CESI, Chieti, Italy

[13] Vestfold Hosp Trust, Unit Ageing & Hlth, Norwegian Advisory Unit, Oslo, Norway

[14] Oslo Univ Hosp, Oslo, Norway

[15] Univ Genoa, Dept Neurosci DINOGMI, Genoa, Italy

[16] Polyclin San Martino Hosp, Neurol Clin, Genoa, Italy

[17] Univ Ljubljana, Univ Med Ctr Ljubljana, Med Fac, Dept Neurol, Ljubljana, Slovenia

[18] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England

[19] Charles Univ Prague, Fac Med 2, Dept Neurol, Memory Clin, Prague, Czech Republic

[20] Motol Univ Hosp, Prague, Czech Republic

[21] St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic

[22] Landspitali Univ Hosp, Reykjavik, Iceland

[23] Hop Univ Strasbourg, Dept Geriatr, Day Hosp Geriatr, Memory Resource & Res Ctr CM2R Strasbourg, Strasbourg, France

[24] Univ Strasbourg, Strasbourg, France

[25] French Natl Ctr Sci Res CNRS, ICube Lab, Team Imagerie Multimodale Integrat Sante IMIS ICO, Strasbourg, France

[26] French Natl Ctr Sci Res CNRS, FMTS, Team Imagerie Multimodale Integrat Sante IMIS ICO, Strasbourg, France

[27] UCL, London & Essex Partnership Univ NHS Fdn Trust, London, England

[28] Univ Padua, Dept Neurosci, Padua, Italy

[29] Fdn Osped San Camillo, Venice, Italy

[30] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Neuroimaging Sci, Dept Neuroimaging, London, England

[31] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

来源：

ALZHEIMERS & DEMENTIA | 2019年 / 15卷 / 03期

基金：

加拿大健康研究院; 瑞典研究理事会; 美国国家卫生研究院;

关键词：

Dementia; Alzheimer's disease; Dementia with Lewy bodies; Medial temporal atrophy; Posterior atrophy frontal atrophy; Typical Alzheimer's disease atrophy pattern; Limbic-predominant atrophy pattern; Hippocampal spearing atrophy pattern; Minimal-atrophy pattern; Differential diagnosis; Magnetic resonance imaging; Neuroimaging; VISUAL RATING-SCALES; GRAY-MATTER ATROPHY; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; BRAIN ATROPHY; DEFINED SUBTYPES; MRI; DIAGNOSIS; MANAGEMENT; ADNI;

D O I：

10.1016/j.jalz.2018.09.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Methods: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. Results: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < 001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. Discussion: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB. (C) 2018 Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：400 / 409

页数：10

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