Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance

被引：16
作者：
Zhang, Haozhe [1 ]
Zhou, Yi [1 ]
Xing, Zengzhen [1 ]
Sah, Rajiv Kumar [1 ]
Hu, Junqi [1 ]
Hu, Hailiang [1 ,2 ]
机构：
[1] So Univ Sci & Technol, Sch Med, Dept Biochem, Shenzhen 518055, Peoples R China
[2] Southern Univ Sci & Technol, Key Univ Lab Metab & Hlth Guangdong, Shenzhen 518055, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 21期
基金：
中国国家自然科学基金;
关键词：
androgen metabolism; androgen receptor; anti-androgen therapy; 3-BETA-HYDROXYSTEROID DEHYDROGENASE; UDP-GLUCURONOSYLTRANSFERASES; INDEPENDENT GROWTH; CYP17A1; INHIBITION; BACKDOOR PATHWAY; RECEPTOR; CASTRATION; TESTOSTERONE; ABIRATERONE; EXPRESSION;
D O I：
10.3390/ijms232113521
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
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页数：15
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