Emerging EPO and EPO receptor regulators and signal transducers

被引：138

作者：

Kuhrt, David ^{[1
]}

Wojchowski, Don M. ^{[1
,2
]}

机构：

[1] Maine Med Ctr, Res Inst, Div Mol Med, Scarborough, ME 04074 USA

[2] Tufts Univ, Sch Med, Boston, MA 02111 USA

来源：

BLOOD | 2015年 / 125卷 / 23期

基金：

美国国家卫生研究院;

关键词：

ERYTHROPOIETIN RECEPTOR; ERYTHROID-DIFFERENTIATION; INEFFECTIVE ERYTHROPOIESIS; K-RAS; JAK2; ACTIVATION; EXPRESSION; SURVIVAL; GROWTH; IRON;

D O I：

10.1182/blood-2014-11-575357

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), rat sarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/MEK/ERK), and phosphatidylinositol 3-kinase (PI3K) pathways. Contemporary genetic, bioinformatic, and proteomic approaches continue to uncover new clinically relevant modulators of EPO and EPOR expression, and EPO's biological effects. This Spotlight review highlights such factors and their emerging roles during erythropoiesis and anemia.

引用

页码：3536 / 3541

页数：6

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