Pharmacology of Antiarrhythmic Drugs in Elderly Patients

被引：10

作者：

Frishman, William H. ^{[1
]}

Aronow, Wilbert S. ^{[2
]}

机构：

[1] New York Med Coll, Westchester Cty Med Ctr, Dept Med, Valhalla, NY 10595 USA

[2] New York Med Coll, Westchester Cty Med Ctr, Div Cardiol, Valhalla, NY 10595 USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2012年 / 28卷 / 04期

关键词：

Antiarrhythmic drugs; Arrhythmias; Tachyarrhythmias; Bradyarrhythmias; Pharmacokinetics; Pharmacotherapy; Elderly; CONGESTIVE-HEART-FAILURE; COMPLEX VENTRICULAR ARRHYTHMIAS; ACUTE MYOCARDIAL-INFARCTION; SUDDEN CARDIAC DEATH; LOW-DOSE AMIODARONE; ATRIAL-FIBRILLATION; RANDOMIZED-TRIAL; ALPHA-1-ACID GLYCOPROTEIN; CREATININE CLEARANCE; SINUS RHYTHM;

D O I：

10.1016/j.cger.2012.07.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Bradyarrhythmias and tachyarrhythmias are common in elderly patients as a result of aging and acquired cardiac disease. Antiarrhythmic drugs are effective in elderly patients for the management of supraventricular and ventricular arrhythmias; however, dosing of drugs must be performed with care because of age-related changes in drug pharmacokinetics, the presence of concomitant disease, and frequent drug-drug interactions. Despite the large number of antiarrhythmic drugs having different electrophysiologic actions, as described in this article, only the beta-blockers have been shown to be effective in reducing mortality and to lack proarrhythmic actions.

引用

页码：575 / +

页数：42

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