Pharmacology of Antiarrhythmic Drugs in Elderly Patients

被引：10
作者：
Frishman, William H. [1 ]
Aronow, Wilbert S. [2 ]
机构：
[1] New York Med Coll, Westchester Cty Med Ctr, Dept Med, Valhalla, NY 10595 USA
[2] New York Med Coll, Westchester Cty Med Ctr, Div Cardiol, Valhalla, NY 10595 USA
来源：
CLINICS IN GERIATRIC MEDICINE | 2012年 / 28卷 / 04期
关键词：
Antiarrhythmic drugs; Arrhythmias; Tachyarrhythmias; Bradyarrhythmias; Pharmacokinetics; Pharmacotherapy; Elderly; CONGESTIVE-HEART-FAILURE; COMPLEX VENTRICULAR ARRHYTHMIAS; ACUTE MYOCARDIAL-INFARCTION; SUDDEN CARDIAC DEATH; LOW-DOSE AMIODARONE; ATRIAL-FIBRILLATION; RANDOMIZED-TRIAL; ALPHA-1-ACID GLYCOPROTEIN; CREATININE CLEARANCE; SINUS RHYTHM;
D O I：
10.1016/j.cger.2012.07.001
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Bradyarrhythmias and tachyarrhythmias are common in elderly patients as a result of aging and acquired cardiac disease. Antiarrhythmic drugs are effective in elderly patients for the management of supraventricular and ventricular arrhythmias; however, dosing of drugs must be performed with care because of age-related changes in drug pharmacokinetics, the presence of concomitant disease, and frequent drug-drug interactions. Despite the large number of antiarrhythmic drugs having different electrophysiologic actions, as described in this article, only the beta-blockers have been shown to be effective in reducing mortality and to lack proarrhythmic actions.
引用
收藏
页码：575 / +
页数：42
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