Dynamic profile for the detection of anti-SARS-CoV-2 antibodies using four immunochromatographic assays

被引：42
作者：
Demey, Baptiste [1 ,2 ]
Daher, Nagib [3 ]
Francois, Catherine [1 ,2 ]
Lanoix, Jean-Philippe [2 ,4 ]
Duverlie, Gilles [1 ,2 ]
Castelain, Sandrine [1 ,2 ]
Brochot, Etienne [1 ,2 ]
机构：
[1] Amiens Univ, Dept Virol, Med Ctr, Amiens, France
[2] Jules Verne Univ Picardie, AGIR Res Unit, EA4294, Amiens, France
[3] Univ Hosp, Dept Gynecol Obstet, Amiens, France
[4] Univ Hosp, Infect Dis Dept, Amiens, France
来源：
JOURNAL OF INFECTION | 2020年 / 81卷 / 02期
关键词：
SARS-CoV-2; COVID-19; Antibody; Lateral flow assay;
D O I：
10.1016/j.jinf.2020.04.033
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In order to fight the SARS-CoV-2 pandemic infection, there is a growing need and demand for diagnostic tools that are complementary and different from the RT-PCR currently in use. Multiple serological tests are or will be very soon available but need to be evaluated and validated. We have thus tested 4 immunochromatographic tests for the detection of antibodies to SARS-CoV-2. In addition, we assessed the kinetics of antibody appearance using these assays in 22 patients after they were tested positive by RT-PCR. We observed great heterogeneity in antibody detection post-symptom onset. The median antibody detection time was between 8 and 10 days according to the manufacturers. All the tests showed a sensitivity of 60 to 80% on day 10 and 100% on day 15. In addition, a single cross-reaction was observed with other human coronavirus infections. Thus, immunochromatographic tests for the detection of anti-SARSCoV-2 antibodies may have their place for the diagnostic panel of COVID-19. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：E6 / E10
页数：5
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