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- [24] Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular Chondrocytes requires a decrease of Sp1•Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (08) : 4850 - 4865