Evaluation of the prognostic significance of CDK6 in breast cancer

Cyclin-dependent kinase (CDK) gene family is an important cell cycle progression regulator, which may function as a tumor suppressor. We performed a systematic onco-informatics analysis to investigate the prognostic value ofCDK6in breast cancer.CDK6expression was evaluated using the Oncomine and UALCAN database. The relevance betweenCDK6level and clinical parameters and survival data in breast cancer was analyzed using the bc-GenExMiner, and Kaplan-meier plotter databases. The methylation status and heat map ofCDK6were analyzed by utilizing the UCSC Xena and UALCAN. It was identified thatCDK6was under-expressed in different subtypes of breast cancer. Estrogen receptor (ER) and progesterone receptor (PR) were negatively correlated withCDK6expression. On the other hand, nottingham prognostic index (NPI), human epidermal growth factor receptor-2 (HER-2) status, basal-like status, scarff-bloom-richardson (SBR) grade, and triple-negative status were positively correlated withCDK6level in breast cancer samples with respect to normal tissues. Besides, a positive correlation betweenCDK6and pronecroptosis E3 ubiquitin ligase (PELI1) gene expression was confirmed. Our study revealed thatCDK6might be used as a biomarker for breast cancer prognosis withPELI1. However, more comprehensive experimental data are needed to clarify the value ofCDK6 in breast cancer.