What should you know about limbic encephalitis?

被引：25

作者：

Machado, Sara ^{[1
,2
]}

Pinto, Amelia Nogueira ^{[1
]}

Irani, Sarosh R. ^{[3
]}

机构：

[1] Hosp Prof Doutor Fernando Fonseca, Dept Neurol, P-2720276 Amadora, Portugal

[2] Natl Hosp Neurol & Neurosurg, UCL Inst Neurol, London WC1N 3BG, England

[3] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX1 2JD, England

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2012年 / 70卷 / 10期

关键词：

limbic autoimmune encephalitis; encephalopathy; intracellular antigens; membrane surface antigens; VGKC-complex; LGI1; CASPR2; N-methylaspartate; paraneoplastic syndrome; immunotherapy; POTASSIUM CHANNEL AUTOIMMUNITY; ACID DECARBOXYLASE ANTIBODIES; ANTI-NMDAR ENCEPHALITIS; STIFF MAN SYNDROME; RECEPTOR ANTIBODIES; PROGRESSIVE ENCEPHALOMYELITIS; NEUROLOGICAL SYNDROMES; DIAGNOSTIC-CRITERIA; ADULT LIFE; DISORDERS;

D O I：

10.1590/S0004-282X2012001000012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autoimmune encephalitis is an inflammatory disorder characterized by a subacute impairment of short-term memory, psychiatric features and seizures. It is often associated with a variety of other neurological symptoms, and its differential diagnosis is wide, leading to challenges in its recognition. It used to be regarded as a rare disease, usually paraneoplastic and with poor prognosis. However, with the recent recognition of membrane-surface directed antibodies, it is now known that in a substantial proportion of cases there is no association with any malignancy and there is a good prognosis if treated. Hence, early recognition and prompt initiation of immunotherapies are of great importance.

引用

页码：817 / 822

页数：6

共 39 条

[1] Paraneoplastic disorders of the central nervous system: Update on diagnostic criteria and treatment [J].

Bataller, L ;

Dalmau, JO .

SEMINARS IN NEUROLOGY, 2004, 24 (04) :461-471

[2] Limbic encephalitis: A cause of temporal lobe epilepsy with onset in adult life [J].

Bien, Christian G. ;

Elger, Christian E. .

EPILEPSY & BEHAVIOR, 2007, 10 (04) :529-538

[3] GABAB receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders [J].

Boronat, A. ;

Sabater, L. ;

Saiz, A. ;

Dalmau, J. ;

Graus, F. .

NEUROLOGY, 2011, 76 (09) :795-800

[4] SUBACUTE ENCEPHALITIS OF LATER ADULT LIFE - MAINLY AFFECTING THE LIMBIC AREAS [J].

BRIERLEY, JB ;

CORSELLIS, JAN ;

HIERONS, R ;

NEVIN, S .

BRAIN, 1960, 83 (03) :357-&

[5]

CARR I, 1982, LANCET, V1, P844

[6] Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders [J].

Dalmau, J ;

Gultekin, SH ;

Voltz, R ;

Hoard, R ;

DesChamps, T ;

Balmaceda, C ;

Batchelor, T ;

Gerstner, E ;

Eichen, J ;

Frennier, J ;

Posner, JB ;

Rosenfeld, MR .

BRAIN, 1999, 122 :27-39

[7] Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma [J].

Dalmau, Josep ;

Tuzun, Erdem ;

Wu, Hai-yan ;

Masjuan, Jaime ;

Rossi, Jeffrey E. ;

Voloschin, Alfredo ;

Baehring, Joachim M. ;

Shimazaki, Haruo ;

Koide, Rej ;

King, Dale ;

Mason, Warren ;

Sansing, Lauren H. ;

Dichter, Marc A. ;

Rosenfeld, Myrna R. ;

Lynch, David R. .

ANNALS OF NEUROLOGY, 2007, 61 (01) :25-36

[8] Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis [J].

Dalmau, Josep ;

Lancaster, Eric ;

Martinez-Hernandez, Eugenia ;

Rosenfeld, Myrna R. ;

Balice-Gordon, Rita .

LANCET NEUROLOGY, 2011, 10 (01) :63-74

[9] Limbic encephalitis and hyperactive foci on PET scan [J].

Fakhoury, T ;

Abou-Khalil, B ;

Kessler, RM .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 1999, 8 (07) :427-430

[10] Analysis of relapses in anti-NMDAR encephalitis [J].

Gabilondo, I. ;

Saiz, A. ;

Galan, L. ;

Gonzalez, V. ;

Jadraque, R. ;

Sabater, L. ;

Sans, A. ;

Sempere, A. ;

Vela, A. ;

Villalobos, F. ;

Vinals, M. ;

Villoslada, P. ;

Graus, F. .

NEUROLOGY, 2011, 77 (10) :996-999

← 1 2 3 4 →