Recombinant canine distemper virus serves as bivalent live vaccine against rabies and canine distemper

被引：43

作者：

Wang, Xijun ^{[2
]}

Feng, Na ^{[1
]}

Ge, Jinying ^{[2
]}

Shuai, Lei ^{[2
]}

Peng, Liyan ^{[2
]}

Gao, Yuwei ^{[1
]}

Yang, Songtao ^{[1
]}

Xia, Xianzhu ^{[1
]}

Bu, Zhigao ^{[2
]}

机构：

[1] Acad Mil Med Sci, Inst Mil Vet, Changchun 130122, Peoples R China

[2] Chinese Acad Agr Sci, Key Lab Vet Publ Hlth, Minist Agr, State Key Lab Vet Biotechnol,Harbin Vet Res Inst, Harbin 150001, Peoples R China

来源：

VACCINE | 2012年 / 30卷 / 34期

关键词：

Rabies; Canine distemper; Recombinant canine distemper virus; Vaccine; GLYCOPROTEIN; CHALLENGE; IMMUNITY; IMMUNIZATION; PATHOGENESIS; POLYMERASE; PROTECTION; PRIMATES; ANTIBODY; MICE;

D O I：

10.1016/j.vaccine.2012.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effective, safe, and affordable rabies vaccines are still being sought. Attenuated live vaccine has been widely used to protect carnivores from canine distemper. In this study, we generated a recombinant canine distemper virus (CDV) vaccine strain, rCDV-RVG, expressing the rabies virus glycoprotein (RVG) by using reverse genetics. The recombinant virus rCDV-RVG retained growth properties similar to those of vector CDV in Vero cell culture. Animal studies demonstrated that rCDV-RVG was safe in mice and dogs. Mice inoculated intracerebrally or intramuscularly with rCDV-RVG showed no apparent signs of disease and developed a strong rabies virus (RABV) neutralizing antibody response, which completely protected mice from challenge with a lethal dose of street virus. Canine studies showed that vaccination with rCDV-RVG induced strong and long-lasting virus neutralizing antibody responses to RABV and CDV. This is the first study demonstrating that recombinant CDV has the potential to serve as bivalent live vaccine against rabies and canine distemper in animals. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5067 / 5072

页数：6

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