Lnc-chop Promotes Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor and Inflammatory Environments

被引：69

作者：

Gao, Yunhuan

Wang, Tiantian

Li, Yuanyuan

Zhang, Yuan

Yang, Rongcun

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

[2] Nankai Univ, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China

[3] Nankai Univ, Sch Med, Dept Immunol, Tianjin 300071, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY | 2018年 / 200卷 / 08期

基金：

中国国家自然科学基金; 以色列科学基金会;

关键词：

ENDOPLASMIC-RETICULUM; GENE-EXPRESSION; NONCODING RNAS; MESSENGER-RNA; CANCER; TRANSCRIPTION; DIFFERENTIATION; ACTIVATION; CHROMATIN; MECHANISM;

D O I：

10.4049/jimmunol.1701721

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSCs) are major regulators of immune responses in cancer. Both C/EBP homologous protein (CHOP) and C/EBP beta play a critical role in regulating immunosuppressive function of MDSCs. In this study, we identified a novel long noncoding RNA termed as lnc-chop in MDSCs, which may interact with CHOP and the C/EBP beta isoform liver-enriched inhibitory protein. The binding of lnc-chop with both CHOP and the C/EBP beta isoform liver-enriched inhibitory protein promoted the activation of C/EBP beta and upregulated the expression of arginase-1, NO synthase 2, NADPH oxidase 2, and cyclooxygenase-2, which are related to the immunosuppressive function of MDSCs in inflammatory and tumor environments. Additionally, lnc-chop also promoted the enrichment of H3K4me3 on the promoter region of arginase-1, NO synthase 2, NADPH oxidase 2, and cyclooxygenase-2. These findings suggest an important role of lnc-chop in controlling immunosuppressive function of MDSCs in the tumor environment.

引用

页码：2603 / 2614

页数：12

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